Modelled DT Structure
Method: multi-sequence alignment based machine learning
Detail: Structure Info
Drug Transporter (DT) Information
| General Information of DT | |||||
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| DT ID | DTD0427 | ||||
| Gene Name | SLC5A7 | ||||
| Protein Name | High affinity choline transporter 1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
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| Synonyms | CHT; CHT1; CMS20; HMN7A; Hemicholinium-3-sensitive choline transporter; SLC5A7; Solute carrier family 5 member 7 | ||||
| DT Family | Solute:Sodium Symporter (SSS) Family ; | ||||
| Tissue Specificity | Expressed in putamen, spinal cord and medulla.Specific for cholinergic neurons. | ||||
| Function | This sodium ion- and chloride ion-dependent transporter imports choline from the extracellular space into the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. | ||||
| Endogenous Substrate(s) | Choline | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of High affinity choline transporter 1 |
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(β) Cell Distribution Level of High affinity choline transporter 1 |
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(γ) Organelle Distribution Level of High affinity choline transporter 1 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of High affinity choline transporter 1 |
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(δ) Epigenetic Regulation of High affinity choline transporter 1 |
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(ε) Exogenous Modulation of High affinity choline transporter 1 |
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Structural Variability Data of This DT |
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(γ) Outward/inward-facing Conformation |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of High affinity choline transporter 1 |
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(β) Disease-specific Protein Abundances of High affinity choline transporter 1 |
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(γ) Species- and Tissue-specific DT Abundances |
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| Molecular Transporting Profile of This DT | |||||
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Full List of Drug(s) Transported by This DT |
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Withdrawn, Discontinued or Preclinical Drug |
Click to Show/Hide the Full List of Drug: 1 Drugs in Total | ||||
| Drug Name | Highest Status | Detail | Indication | ICD 11 | Ref |
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Triethylcholine
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Preclinical | Drug Info | Glaucoma | 9C61 | [1] |
| References | |||||
| 1 | The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY. Nucleic Acids Res. 2018 Jan 4;46(D1):D1091-D1106. (familyId=172) | ||||
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