Detail Information of DT Wildtype Structure
| General Information of Drug Transporter (DT) | ||||||
|---|---|---|---|---|---|---|
| DT ID | DTD0427 Transporter Info | |||||
| Gene Name | SLC5A7 | |||||
| Transporter Name | High affinity choline transporter 1 | |||||
| Gene ID | ||||||
| UniProt ID | ||||||
| Experimental Structures of This DT | ||||||
| PDB ID | Scanning Method | Resolution | Expression System | Details | Ref | |
| 8J74 | EM | 3.6 Å | Homo sapiens | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A/B | |||||
| Sequence Length | 580 | Mutation | No | |||
| 8J75 | EM | 3.6 Å | Homo sapiens | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 580 | Mutation | No | |||
| 8J76 | EM | 3.7 Å | Homo sapiens | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 580 | Mutation | No | |||
| 8J77 | EM | 3.7 Å | Homo sapiens | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 580 | Mutation | No | |||
| 8ZQO | EM | 2.8 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 580 | Mutation | No | |||
| 8ZQP | EM | 3.1 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 580 | Mutation | No | |||
| 8ZQQ | EM | 2.5 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 580 | Mutation | No | |||
| 8ZQR | EM | 3.6 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 580 | Mutation | No | |||
| Modelled Structures of This DT | ||||||
| Click to Save PDB File in PDB Format | ||||||
| Detail Information of Modelled Structures | ||||||
| Method | multi-sequence alignment based machine learning | |||||
| AlphaFold Protein Structure Database | ||||||
| References | ||||||
| 1 | Transport mechanism of presynaptic high-affinity choline uptake by CHT1. Nat Struct Mol Biol. 2024;31(4):701-709. | |||||
| 2 | Ion coupling and inhibitory mechanisms of the human presynaptic high-affinity choline transporter CHT1. Structure. 2025;33(2):321-329.e5. | |||||
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