Drug Transporter (DT) Information

General Information of DT
DT ID DTD0382
Gene Name SLC4A11
Protein Name Sodium bicarbonate transporter-like protein 11
Gene ID
83959
UniProt ID
Q8NBS3
TCDB ID
2.A.31.4.1
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms BTR1; Bicarbonate transporter-related protein 1; CDPD1; CHED; CHED2; NaBC1; SLC4A11; Sodium borate cotransporter 1; Solute carrier family 4 member 11; dJ794I6.2
DT Family Anion Exchanger (AE) Family ;
Tissue Specificity Widely expressed. Highly expressed in kidney,testis, salivary gland, thyroid, trachea and corneal endothelium.Not detected in retina and lymphocytes.
Function This transporter which plays an important role in sodium-mediated fluid transport in different organs.
Endogenous Substrate(s) Boride
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium bicarbonate transporter-like protein 11
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium bicarbonate transporter-like protein 11
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium bicarbonate transporter-like protein 11
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Sodium bicarbonate transporter-like protein 11
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Sodium bicarbonate transporter-like protein 11
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sodium bicarbonate transporter-like protein 11
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium bicarbonate transporter-like protein 11
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(α) Mutation-induced Structural Variation
Mutation-induced Structural Variation (MSV)

(γ) Outward/inward-facing Conformation
Outward/inward-facing Conformation (OIC)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium bicarbonate transporter-like protein 11
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium bicarbonate transporter-like protein 11
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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