Modelled DT Structure
Method: multi-sequence alignment based machine learning
Detail: Structure Info
Drug Transporter (DT) Information
| General Information of DT | |||||
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| DT ID | DTD0376 | ||||
| Gene Name | SLC49A1 | ||||
| Protein Name | Feline leukemia virus subgroup C receptor-related protein 1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
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| Synonyms | AXPC1; FLVCR; FLVCR1; Feline leukemia virus subgroup C receptor; MFSD7B; PCA; PCARP; SLC49A1; hFLVCR | ||||
| DT Family | Major Facilitator Superfamily (MFS) | ||||
| Feline Leukemia Virus Subgroup C Receptor (FLVCR)/Heme Importer Family | |||||
| Function | This transporter exports cytoplasmic heme, coproporphyrin and protoporphyrin IX. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythtopoiesis, a process in which heme synthesis intensifies. | ||||
| Endogenous Substrate(s) | Water | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Feline leukemia virus subgroup C receptor-related protein 1 |
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(β) Cell Distribution Level of Feline leukemia virus subgroup C receptor-related protein 1 |
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(γ) Organelle Distribution Level of Feline leukemia virus subgroup C receptor-related protein 1 |
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Regulatory Variability Data of This DT |
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(α) Microbiota Influence of Feline leukemia virus subgroup C receptor-related protein 1 |
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(β) Post-translational Modification of Feline leukemia virus subgroup C receptor-related protein 1 |
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(δ) Epigenetic Regulation of Feline leukemia virus subgroup C receptor-related protein 1 |
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(ε) Exogenous Modulation of Feline leukemia virus subgroup C receptor-related protein 1 |
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Structural Variability Data of This DT |
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(γ) Outward/inward-facing Conformation |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Feline leukemia virus subgroup C receptor-related protein 1 |
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(β) Disease-specific Protein Abundances of Feline leukemia virus subgroup C receptor-related protein 1 |
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(γ) Species- and Tissue-specific DT Abundances |
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| Molecular Transporting Profile of This DT | |||||
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Full List of Drug(s) Transported by This DT |
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Phase 3 Drug |
Click to Show/Hide the Full List of Drug: 1 Drugs in Total | ||||
| Drug Name | Highest Status | Detail | Indication | ICD 11 | Ref |
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Quercetin
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Phase 3 | Drug Info | Coronary artery disease | BA6Z | [1] |
| References | |||||
| 1 | The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.1.28.1) | ||||
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