Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0376 Transporter Info
Gene Name	SLC49A1
Transporter Name	Feline leukemia virus subgroup C receptor-related protein 1
Gene ID	28982
UniProt ID	Q9Y5Y0

Post-Translational Modification of This DT
Overview ofSLC49A1 Modification Sites with Functional and Structural Information
Sequence	M A R P D D E E G A A V A P G H P L A K G Y L P L P R G A P V G K E S V E L Q N G P K A G T F P V N G A P R D S L A A A S G V L G G P Q T P L A P E E E T Q A R L L P A G A G A E T P G A E S S P L P L T A L S P R R F V V L L I F S L Y S L V N A F Q W I Q Y S I I S N V F E G F Y G V T L L H I D W L S M V Y M L A Y V P L I F P A T W L L D T R G L R L T A L L G S G L N C L G A W I K C G S V Q Q H L F W V T M L G Q C L C S V A Q V F I L G L P S R I A S V W F G P K E V S T A C A T A V L G N Q L G T A V G F L L P P V L V P N T Q N D T N L L A C N I S T M F Y G T S A V A T L L F I L T A I A F K E K P R Y P P S Q A Q A A L Q D S P P E E Y S Y K K S I R N L F K N I P F V L L L I T Y G I M T G A F Y S V S T L L N Q M I L T Y Y E G E E V N A G R I G L T L V V A G M V G S I L C G L W L D Y T K T Y K Q T T L I V Y I L S F I G M V I F T F T L D L R Y I I I V F V T G G V L G F F M T G Y L P L G F E F A V E I T Y P E S E G T S S G L L N A S A Q I F G I L F T L A Q G K L T S D Y G P K A G N I F L C V W M F I G I I L T A L I K S D L R R H N I N I G I T N V D V K A I P A D S P T D Q E P K T V M L S K Q S E S A I
PTM type	X-N-glycosylation X-Phosphorylation X-Ubiquitination X: Amino Acid

N-glycosylation
Asparagine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC49A1			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	265
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC49A1 Asparagine 265 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC49A1			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	273
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC49A1 Asparagine 273 has the potential to affect its expression or activity.
Phosphorylation
Serine	6 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC49A1			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	56
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC49A1 Serine 56 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC49A1			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	61
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC49A1 Serine 61 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC49A1			[5], [6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	95
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC49A1 Serine 95 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC49A1			[5], [7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	96
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC49A1 Serine 96 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC49A1			[8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	104
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC49A1 Serine 104 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC49A1			[9], [10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	536
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC49A1 Serine 536 has the potential to affect its expression or activity.
Threonine	8 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC49A1			[4]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	46
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC49A1 Threonine 46 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC49A1			[3], [11]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	69
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC49A1 Threonine 69 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC49A1			[5], [6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	90
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC49A1 Threonine 90 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC49A1			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	101
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC49A1 Threonine 101 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC49A1			[12]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	401
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC49A1 Threonine 401 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC49A1			[12]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	417
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC49A1 Threonine 417 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC49A1			[12]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	419
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC49A1 Threonine 419 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC49A1			[10], [13]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	538
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC49A1 Threonine 538 has the potential to affect its expression or activity.
Tyrosine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC49A1			[11], [14]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	22
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC49A1 Tyrosine 22 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC49A1			[12]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	398
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC49A1 Tyrosine 398 has the potential to affect its expression or activity.
Ubiquitination
Lysine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC49A1			[15], [16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	33
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC49A1 Lysine 33 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC49A1			[15], [16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	322
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC49A1 Lysine 322 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC49A1			[15], [16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	530
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC49A1 Lysine 530 has the potential to affect its expression or activity.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: FLVC1_HUMAN)
2	UniProt: a worldwide hub of protein knowledge. Nucleic Acids Res. 2019 Jan 8;47(D1):D506-D515.
3	Phosphoproteomic analysis reveals PAK2 as a therapeutic target for lapatinib resistance in HER2-positive breast cancer cells. Biochem Biophys Res Commun. 2018 Oct 20;505(1):187-193.
4	HIV-1 Activates T Cell Signaling Independently of Antigen to Drive Viral Spread. Cell Rep. 2017 Jan 24;18(4):1062-1074.
5	Phosphoproteomics reveals ALK promote cell progress via RAS/ JNK pathway in neuroblastoma. Oncotarget. 2016 Nov 15;7(46):75968-75980.
6	Residual tissue repositories as a resource for population-based cancer proteomic studies. Clin Proteomics. 2018 Aug 3;15:26.
7	Identification of Mediator Kinase Substrates in Human Cells using Cortistatin A and Quantitative Phosphoproteomics. Cell Rep. 2016 Apr 12;15(2):436-50.
8	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
9	Capillary Zone Electrophoresis-Tandem Mass Spectrometry for Large-Scale Phosphoproteomics with the Production of over 11,000 Phosphopeptides from the Colon Carcinoma HCT116 Cell Line. Anal Chem. 2019 Feb 5;91(3):2201-2208.
10	Quantitative Phosphoproteome Analysis of Clostridioides difficile Toxin B Treated Human Epithelial Cells. Front Microbiol. 2018 Dec 17;9:3083.
11	An integrated strategy for highly sensitive phosphoproteome analysis from low micrograms of protein samples. Analyst. 2018 Jul 23;143(15):3693-3701.
12	iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics. Mol Cell Proteomics. 2012 Jun;11(6):M111.014423.
13	Modulation of Cl- signaling and ion transport by recruitment of kinases and phosphatases mediated by the regulatory protein IRBIT. Sci Signal. 2018 Oct 30;11(554):eaat5018.
14	Sensitive, Robust, and Cost-Effective Approach for Tyrosine Phosphoproteome Analysis. Anal Chem. 2017 Sep 5;89(17):9307-9314.
15	Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 2011 Oct 21;44(2):325-40.
16	Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. J Proteome Res. 2012 Feb 3;11(2):796-807.

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Detail Information of Post-Translational Modifications

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