Drug Transporter (DT) Information

General Information of DT
DT ID DTD0371
Gene Name SLC45A4
Protein Name Solute carrier family 45 member 4
Gene ID
57210
UniProt ID
Q5BKX6
TCDB ID
2.A.2.4.7
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms KIAA1126; SLC45A4; Solute carrier 45 member 4
DT Family Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family ;
Function This proton symporter tranaporter mediates the transport of sucrose.
Endogenous Substrate(s) Sucrose
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Solute carrier family 45 member 4
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Solute carrier family 45 member 4
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Solute carrier family 45 member 4
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Solute carrier family 45 member 4
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Solute carrier family 45 member 4
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Solute carrier family 45 member 4
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Solute carrier family 45 member 4
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Solute carrier family 45 member 4
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Solute carrier family 45 member 4
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Sucrose
 Phase 4 Drug Info Retinopathy of prematurity 9B71.3 [1]
References
1 The SLC45 gene family of putative sugar transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):655-60.

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