Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00131
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| Drug Name |
Sucrose
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| Synonyms |
57-50-1; Amerfand; Amerfond; Beet sugar; CCRIS 2120; CHEBI:17992; Cane sugar; Confectioner's sugar; D(+)-Saccharose; D(+)-Sucrose; D-(+)-Saccharose; D-Saccharose; D-Sucrose; Granulated sugar; HSDB 500; Microse; Rock candy; Rohrzucker; Saccharose; Saccharum; Sacharose; Sucraloxum [INN-Latin]; Sucrose [USAN:JAN]; Sucrose, dust; Sucrose, pure; Table sugar; White sugar; alpha-D-Glucopyranosyl beta-D-fructofuranoside; beta-D-Fructofuranosyl alpha-D-glucopyranoside; beta-D-Fructofuranosyl-alpha-D-glucopyranoside; sacarosa; sugar
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| Drug Type |
Small molecular drug
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| Indication | Retinopathy of prematurity [ICD11:9B71.3] | Phase 4 | [1] | |||
| Structure |
|
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| 3D MOL | 2D MOL | |||||
| Formula |
C12H22O11
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| Canonical SMILES |
C(C1C(C(C(C(O1)OC2(C(C(C(O2)CO)O)O)CO)O)O)O)O
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| InChI |
InChI=1S/C12H22O11/c13-1-4-6(16)8(18)9(19)11(21-4)23-12(3-15)10(20)7(17)5(2-14)22-12/h4-11,13-20H,1-3H2/t4-,5-,6-,7-,8+,9-,10+,11-,12+/m1/s1
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| InChIKey |
CZMRCDWAGMRECN-UGDNZRGBSA-N
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| CAS Number |
CAS 57-50-1
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| Pharmaceutical Properties | Molecular Weight | 342.3 | Topological Polar Surface Area | 190 | ||
| Heavy Atom Count | 23 | Rotatable Bond Count | 5 | |||
| Hydrogen Bond Donor Count | 8 | Hydrogen Bond Acceptor Count | 11 | |||
| XLogP |
-3.7
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| PubChem CID | ||||||
| PubChem SID |
3137376
,3194
,3389
,6436115
,6436116
,6436204
,7847093
,7887852
,7890628
,8011621
,8011923
,8020622
,8022577
,8024860
,8024864
,8027366
,8028161
,8143928
,8153723
,818878
,820865
,823014
,823458
,823537
,825314
,825582
,825586
,826415
,826659
,826950
,826952
,826953
,827036
,828601
,828646
,829805
,831374
,832319
,832408
,833228
,833813
,838627
,839070
,839082
,839090
,841538
,854919
,855298
,855299
,855300
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| ChEBI ID |
CHEBI:17992
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | SLC45A2 | Transporter Info | Membrane-associated transporter protein | Substrate | [2] | |
| SLC45A3 | Transporter Info | Solute carrier family 45 member 3 | Substrate | [3] | ||
| SLC45A4 | Transporter Info | Solute carrier family 45 member 4 | Substrate | [4] | ||
| References | ||||||
| 1 | ClinicalTrials.gov (NCT00921544) Sucrose Analgesia for the Reduction of Pain During Retinopathy of Prematurity Screening | |||||
| 2 | Identification of amino acids important for substrate specificity in sucrose transporters using gene shuffling. J Biol Chem. 2012 Aug 31;287(36):30296-304. | |||||
| 3 | Putative role of the H(+)/sucrose symporter SLC45A3 as an osmolyte transporter in the kidney. Pflugers Arch. 2016 Aug;468(8):1353-62. | |||||
| 4 | The SLC45 gene family of putative sugar transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):655-60. | |||||
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