Drug Transporter (DT) Information

General Information of DT
DT ID DTD0369
Gene Name SLC45A2
Protein Name Membrane-associated transporter protein
Gene ID
51151
UniProt ID
Q9UMX9
TCDB ID
2.A.2.4.9
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms 1A1; AIM1; MATP; Melanoma antigen AIM1; OCA4; Protein AIM-1; SHEP5; SLC45A2; Solute carrier family 45 member 2
DT Family Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family ;
Tissue Specificity Expressed in most melanoma cell lines andmelanocytes.
Function This tranporter may meditates the transport of substances required for melanin biosynthesis.
Endogenous Substrate(s) Sucrose
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Membrane-associated transporter protein
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Membrane-associated transporter protein
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Membrane-associated transporter protein
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Membrane-associated transporter protein
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Membrane-associated transporter protein
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Membrane-associated transporter protein
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Membrane-associated transporter protein
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Membrane-associated transporter protein
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Membrane-associated transporter protein
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Sucrose
 Phase 4 Drug Info Retinopathy of prematurity 9B71.3 [1]
References
1 Identification of amino acids important for substrate specificity in sucrose transporters using gene shuffling. J Biol Chem. 2012 Aug 31;287(36):30296-304.

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