Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0369 Transporter Info
Gene Name SLC45A2
Transporter Name Membrane-associated transporter protein
Gene ID
51151
UniProt ID
Q9UMX9

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.2: Basic helix-loop-helix factors

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        MITF 

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       Transcriptional Phenomenon1

 Activation of SLC45A2 gene in melanoma condition [1]

TF Protein Name

 Microphthalmia-associated transcription factor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC45A2 gene in melanoma condition, which leads to an increased expression of the drug transporter Membrane-associated transporter protein.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        HNF4A 

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       Transcriptional Phenomenon1

 Binding to SLC45A2 gene in health condition [2]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC45A2 gene in health condition, which leads to an affected expression of the drug transporter Membrane-associated transporter protein.

      Class2.3: C2H2 zinc finger factors

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        EGR1 

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       Transcriptional Phenomenon1

 Activation of SLC45A2 gene in UV irradiation condition [3]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to activate the transcription of SLC45A2 gene in UV irradiation condition, which leads to an increased expression of the drug transporter Membrane-associated transporter protein.

TF Superclass6: Immunoglobulin fold

      Class6.2: STAT domain factors

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        STAT3 

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       Transcriptional Phenomenon1

 Binding to SLC45A2 gene in glioblastoma multiforme condition [4]

TF Protein Name

 Signal transducer and activator of transcription 3 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Signal transducer and activator of transcription 3 (STAT3) has been reported to bind to the transcription of SLC45A2 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Membrane-associated transporter protein.

      Class6.4: Runt domain factors

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        RUNX3 

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       Transcriptional Phenomenon1

 Direct binding to SLC45A2 gene [5]

TF Protein Name

 Runt-related transcription factor 3 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Runt-related transcription factor 3 (RUNX3) can directly bind to the SLC45A2 gene, which in turn affects the expression or function of the drug transporter Membrane-associated transporter protein.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

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        NFIC 

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       Transcriptional Phenomenon1

 Direct binding to SLC45A2 gene [6]

TF Protein Name

 Nuclear factor 1 C-type Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Nuclear factor 1 C-type (NFIC) can directly bind to the SLC45A2 gene, which in turn affects the expression or function of the drug transporter Membrane-associated transporter protein.
References
1 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
2 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
3 Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chip. Genome Biol. 2008;9(11):R166.
4 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
5 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
6 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-365. (ID:ENSG00000164175)

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