Drug Transporter (DT) Information

General Information of DT
DT ID DTD0349
Gene Name SLC39A8
Protein Name Zinc transporter ZIP8
Gene ID
64116
UniProt ID
Q9C0K1
TCDB ID
2.A.5.4.15
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms BCG-induced integral membrane protein in monocyte clone 103 protein; BIGM103; CDG2N; LIV-1 subfamily of ZIP zinc transporter 6; LZT-Hs6; PP3105; SLC39A8; Solute carrier family 39 member 8; ZIP-8; ZIP8; Zinc transporter ZIP8
DT Family Zinc (Zn(2+))-Iron (Fe(2+)) Permease (ZIP) Family ;
Tissue Specificity Expressed in thymus, placenta, lung, liver,pancreas and, to a lower extent, in spleen, testis, ovary, smallintestine, colon, leukocyte, heart. Highest expression is observedin pancreas.
Function This transporter mediates the influx of manganese and zinc. Plays a role in manganese reabsorption in the proximal tubule of the kidney and in manganese uptake into the brain.
Endogenous Substrate(s) Cd2+; Mn2+; Zn2+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Zinc transporter ZIP8
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Zinc transporter ZIP8
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Zinc transporter ZIP8
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Zinc transporter ZIP8
Microbiota Influence (MBI)

(β) Post-translational Modification of Zinc transporter ZIP8
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Zinc transporter ZIP8
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Zinc transporter ZIP8
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Zinc transporter ZIP8
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Zinc transporter ZIP8
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Zinc transporter ZIP8
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Withdrawn, Discontinued or Preclinical Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Zinc salts
 Preclinical Drug Info Arthritis FA5Z [1]
References
1 Zinc transporters ZnT1 (Slc30a1), Zip8 (Slc39a8), and Zip10 (Slc39a10) in mouse red blood cells are differentially regulated during erythroid development and by dietary zinc deficiency. J Nutr. 2008 Nov;138(11):2076-83.

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