General Information of Drug Transporter (DT)
DT ID	DTD0349 Transporter Info
Gene Name	SLC39A8
Protein Name	Zinc transporter ZIP8
Gene ID	64116
UniProt ID	Q9C0K1
Genetic Polymorphisms of DT (GPD)
Genetic Polymorphism	rs13135092
Site of GPD	chr4:102276925 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	A>G
Minor Allele Frequency	A=0.9750/1929 (Global)
Allele A	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Ethanol	N.A.	Alcohol Abuse	Allele A is associated with increased risk of Alcoholism due to ethanol as compared to allele G.		[ 1]
Genotype AA	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Ethanol	N.A.	Alcohol Abuse	Patients with the AA genotype may be at an increased risk of developing alcoholism as compared to patients with the GG genotype. Other genetic and clinical factors may also affect a patient's risk of developing alcoholism.		[ 1]
Genotype AG	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Ethanol	N.A.	Alcohol Abuse	Patients with the AG genotype may be at an increased risk of developing alcoholism as compared to patients with the GG genotype. Other genetic and clinical factors may also affect a patient's risk of developing alcoholism.		[ 1]
Genotype GG	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Ethanol	N.A.	Alcohol Abuse	Patients with the GG genotype may be at a decreased risk of developing alcoholism as compared to patients with the AA or AG genotypes. Other genetic and clinical factors may also affect a patient's risk of developing alcoholism.		[ 1]
References
1	Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits. Nat Neurosci. 2020 Jul;23(7):809-818.

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