Drug Transporter (DT) Information

General Information of DT
DT ID DTD0320
Gene Name SLC36A3
Protein Name Proton-coupled amino acid transporter 3
Gene ID
285641
UniProt ID
Q495N2
TCDB ID
2.A.18.8.4
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms PAT3; Proton/amino acid transporter 3; SLC36A3; Solute carrier family 36 member 3; TRAMD2; Tramdorin-2; tramdorin2
DT Family Amino Acid/Auxin Permease (AAAP) Family ;
Tissue Specificity Specifically expressed in testis.
Function This transporter is expressed only in testes and is an orphan transporter with no known function.
Endogenous Substrate(s) H+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Proton-coupled amino acid transporter 3
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Proton-coupled amino acid transporter 3
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Proton-coupled amino acid transporter 3
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(γ) Transcriptional Regulation of Proton-coupled amino acid transporter 3
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Proton-coupled amino acid transporter 3
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Proton-coupled amino acid transporter 3
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Proton-coupled amino acid transporter 3
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Proton-coupled amino acid transporter 3
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Amino acids
 Approved Drug Info Nutritional deficiency 5B7Z [1]
References
1 Organization and expression of the SLC36 cluster of amino acid transporter genes. Mamm Genome. 2004 Feb;15(2):114-25.

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