Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0320 Transporter Info
Gene Name	SLC36A3
Transporter Name	Proton-coupled amino acid transporter 3
Gene ID	285641
UniProt ID	Q495N2

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
Benzo(a)pyrene	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene results in increased methylation of SLC36A3 5' UTR		[2]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Benzo(a)pyrene results in increased methylation of SLC36A3 promoter		[2]
Regulation Mechanism			Transcription Factor Info
bisphenol A	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol A results in decreased expression of SLC36A3 mRNA		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	bisphenol A results in decreased methylation of SLC36A3 gene		[3]
Regulation Mechanism			Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to SLC36A3 gene		[4]
Regulation Mechanism			Transcription Factor Info
Valproic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid results in increased methylation of SLC36A3 gene		[5]
Regulation Mechanism			Transcription Factor Info
Drug in Phase 2 Trial
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bisphenol A inhibits the expression of SLC36A3		[1]

References
1	Comparison of transcriptome expression alterations by chronic exposure to low-dose bisphenol A in different subtypes of breast cancer cells. Toxicol Appl Pharmacol. 2019 Dec 15;385:114814.
2	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
3	DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019;11(1):138.
4	Identification of potential target genes of ROR-alpha in THP1 and HUVEC cell lines. Exp Cell Res. 2017;353(1):6-15.
5	Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.