Modelled DT Structure
Method:homology modeling
Template PDB:5VRF_A; 2ENK_A
Identity:25.806%;100%
Minimized Score:-738.414 kcal/mol
Detail: Structure Info
Drug Transporter (DT) Information
| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0277 | ||||
| Gene Name | SLC30A9 | ||||
| Protein Name | Zinc transporter 9 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
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| Synonyms | BILAPES; C4orf1; GAC63; HuEL; Human embryonic lung protein; SLC30A9; Solute carrier family 30 member 9; ZNT9; ZnT-9 | ||||
| DT Family | Cation Diffusion Facilitator (CDF) Family ; | ||||
| Tissue Specificity | Ubiquitously expressed in fetal and adulttissues and cancer cell lines. | ||||
| Function | This transporter acts as a zinc transporter involved in intracellular zinc homeostasis. | ||||
| Endogenous Substrate(s) | Zn2+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Zinc transporter 9 |
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(β) Cell Distribution Level of Zinc transporter 9 |
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(γ) Organelle Distribution Level of Zinc transporter 9 |
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Regulatory Variability Data of This DT |
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(α) Microbiota Influence of Zinc transporter 9 |
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(β) Post-translational Modification of Zinc transporter 9 |
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(γ) Transcriptional Regulation of Zinc transporter 9 |
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(δ) Epigenetic Regulation of Zinc transporter 9 |
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(ε) Exogenous Modulation of Zinc transporter 9 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Zinc transporter 9 |
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(β) Disease-specific Protein Abundances of Zinc transporter 9 |
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(γ) Species- and Tissue-specific DT Abundances |
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| Molecular Transporting Profile of This DT | |||||
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Full List of Drug(s) Transported by This DT |
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Withdrawn, Discontinued or Preclinical Drug |
Click to Show/Hide the Full List of Drug: 1 Drugs in Total | ||||
| Drug Name | Highest Status | Detail | Indication | ICD 11 | Ref |
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Zinc salts
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Preclinical | Drug Info | Arthritis | FA5Z | [1] |
| References | |||||
| 1 | SLC30A9 mutation affecting intracellular zinc homeostasis causes a novel cerebro-renal syndrome. Brain. 2017 Apr 1;140(4):928-939. | ||||
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