Detail Information of Genetic Polymorphisms
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0277 Transporter Info | ||||
| Gene Name | SLC30A9 | ||||
| Protein Name | Zinc transporter 9 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Genetic Polymorphisms of DT (GPD) | |||||
| Genetic Polymorphism | rs1047626 | ||||
| Site of GPD | chr4:42001654 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | A>C / A>G | ||||
| Minor Allele Frequency | A=0.3716/1861 (Global) | ||||
| Allele A | Click to Show/Hide the Full List of Affected Drugs: 2 Drugs in Total | ||||
| Aspirin | Drug Info | Asthma | Correlated with the decreased aspirin-induced asthma risk in patients (compare with allele G) | [ 1] | |
| Aspirin | N.A. | Aspirin-induced Asthma | Allele A is associated with decreased risk of aspirin-induced asthma when exposed to aspirin in people with Asthma as compared to allele G. | [ 1] | |
| Genotype AA | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Aspirin | N.A. | Aspirin-induced Asthma | Patients with asthma and the AA genotype may have a decreased risk of aspirin induced asthma as compared to people with the AG or GG genotype. Other genetic and clinical factors may also influence a patient's risk of asthma. | [ 1] | |
| Genotype AG | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Aspirin | N.A. | Aspirin-induced Asthma | Patients with asthma and the AG genotype may have an increased risk of aspirin induced asthma as compared to patients with the AA genotype and a decreased risk of aspirin induced asthma as compared to patients with the GG genotype. Other genetic and clinical factors may also influence a patient's risk of asthma. | [ 1] | |
| Genotype GG | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Aspirin | N.A. | Aspirin-induced Asthma | Patients with asthma and the GG genotype may have an increased risk of aspirin induced asthma as compared to people with the AG or AA genotype. Other genetic and clinical factors may also influence a patient's risk of asthma. | [ 1] | |
| References | |||||
| 1 | Exonic variants associated with development of aspirin exacerbated respiratory diseases. PLoS One. 2014 Nov 5;9(11):e111887. | ||||
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