Drug Transporter (DT) Information

General Information of DT
DT ID DTD0276
Gene Name SLC30A7
Protein Name Zinc transporter 7
Gene ID
148867
UniProt ID
Q8NEW0
TCDB ID
2.A.4.4.5
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms SLC30A7; Solute carrier family 30 member 7; ZNT7; ZNTL2; ZnT-7; Znt-like transporter 2
DT Family Cation Diffusion Facilitator (CDF) Family ;
Function This transporter transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis.
Endogenous Substrate(s) Zn2+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Zinc transporter 7
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Zinc transporter 7
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Zinc transporter 7
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Zinc transporter 7
Microbiota Influence (MBI)

(β) Post-translational Modification of Zinc transporter 7
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Zinc transporter 7
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Zinc transporter 7
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Zinc transporter 7
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(γ) Outward/inward-facing Conformation
Outward/inward-facing Conformation (OIC)

General Variability Data of This DT

(α) Genetic Polymorphisms of Zinc transporter 7
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Zinc transporter 7
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Withdrawn, Discontinued or Preclinical Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Zinc salts
 Preclinical Drug Info Arthritis FA5Z [1]
References
1 Znt7 (Slc30a7)-deficient mice display reduced body zinc status and body fat accumulation. J Biol Chem. 2007 Dec 21;282(51):37053-63.

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