Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0276 Transporter Info
Gene Name SLC30A7
Transporter Name Zinc transporter 7
Gene ID
148867
UniProt ID
Q8NEW0

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        ATF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC30A7 gene [1]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-1 Transcription Factor Info

Tissue

 Bone marrow; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-1 (ATF1) can directly bind to the SLC30A7 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 7.

        CEBPB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC30A7 gene [2]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Blood; Breast; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC30A7 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 7.

        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC30A7 gene [3]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Blood; Liver; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC30A7 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 7.

        NFE2L2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC30A7 gene in diabetic kidney disease condition [4]

TF Protein Name

 Nuclear factor erythroid 2-related factor 2 Transcription Factor Info

Studied Phenotype

 Diabetic kidney disease [ICD11: GB61]

Tissue

 Kidney

Related DT Changes

 Up regulating

Experimental Material

 C57BL/6J mice

Detailed Description

 Nuclear factor erythroid 2-related factor 2 (NFE2L2) has been reported to activate the transcription of SLC30A7 gene in diabetic kidney disease condition, which leads to an increased expression of the drug transporter Zinc transporter 7.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        GATA1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC30A7 gene in megakaryocytes condition [5]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC30A7 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Zinc transporter 7.

       Transcriptional Phenomenon2

 Direct binding to SLC30A7 gene [1]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Tissue

 Blood; Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Erythroid transcription factor (GATA1) can directly bind to the SLC30A7 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 7.

        GATA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC30A7 gene in health condition [6]

TF Protein Name

 Endothelial transcription factor GATA-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Endothelial transcription factor GATA-2 (GATA2) has been reported to bind to the transcription of SLC30A7 gene in health condition, which leads to an affected expression of the drug transporter Zinc transporter 7.

        GATA6 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC30A7 gene in gastric cancer condition [7]

TF Protein Name

 Transcription factor GATA-6 Transcription Factor Info

Affected Drug/Substrate

 Metformin

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor GATA-6 (GATA6) has been reported to activate the transcription of SLC30A7 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Zinc transporter 7.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        EGR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC30A7 gene in erythroleukemia condition [8]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC30A7 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Zinc transporter 7.

        KLF5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC30A7 gene [3]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Tissue

 Pancreatic ductal; Stomach

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 5 (KLF5) can directly bind to the SLC30A7 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 7.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC30A7 gene [2]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Bone marrow; Cervix; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC30A7 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 7.

        MTF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC30A7 gene in insulinoma condition [9]

TF Protein Name

 Metal regulatory transcription factor 1 Transcription Factor Info

Affected Drug/Substrate

 Insulin

Studied Phenotype

 Insulinoma [ICD11: 2C10.1]

Tissue

 Pancreas

Related DT Changes

 Up regulating

Experimental Material

 Rat insulinoma cells (RIN5mF)

Detailed Description

 Metal regulatory transcription factor 1 (MTF1) has been reported to activate the transcription of SLC30A7 gene in insulinoma condition, which leads to an increased expression of the drug transporter Zinc transporter 7.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        NANOG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC30A7 gene in HESC condition [10]

TF Protein Name

 Homeobox protein NANOG Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Homeobox protein NANOG (NANOG) has been reported to bind to the transcription of SLC30A7 gene in HESC condition, which leads to an affected expression of the drug transporter Zinc transporter 7.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        E2F1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC30A7 gene [11]

TF Protein Name

 Transcription factor E2F1 Transcription Factor Info

Tissue

 Mesenchymal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F1 (E2F1) can directly bind to the SLC30A7 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 7.

        E2F4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC30A7 gene in health condition [12]

TF Protein Name

 Transcription factor E2F4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor E2F4 (E2F4) has been reported to bind to the transcription of SLC30A7 gene in health condition, which leads to an affected expression of the drug transporter Zinc transporter 7.

        FOXA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC30A7 gene [3]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Tissue

 Breast; Embryo; Liver; Lung; Pancreatic ductal; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC30A7 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 7.

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC30A7 gene [11]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Tissue

 Embryo; Endoderm; Liver; Lung; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC30A7 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 7.

        FOXP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLC30A7 gene in embryonic stem cell condition [13]

TF Protein Name

 Forkhead box protein P1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Forkhead box protein P1 (FOXP1) has been reported to repress the transcription of SLC30A7 gene in embryonic stem cell condition, which leads to a decreased expression of the drug transporter Zinc transporter 7.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 6 TF(s) Regulating This DT

        ELK1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC30A7 gene in health condition [14]

TF Protein Name

 ETS domain-containing protein Elk-1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 ETS domain-containing protein Elk-1 (ELK1) has been reported to activate the transcription of SLC30A7 gene in health condition, which leads to an increased expression of the drug transporter Zinc transporter 7.

        ERG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC30A7 gene [1]

TF Protein Name

 Transcriptional regulator ERG Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional regulator ERG (ERG) can directly bind to the SLC30A7 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 7.

        ETS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC30A7 gene [2]

TF Protein Name

 Protein C-ets-1 Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Kidney; Lung; Prostate; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein C-ets-1 (ETS1) can directly bind to the SLC30A7 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 7.

        FLI1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC30A7 gene in megakaryocytes condition [5]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of SLC30A7 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Zinc transporter 7.

       Transcriptional Phenomenon2

 Direct binding to SLC30A7 gene [2]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal; Umbilical cord blood; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC30A7 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 7.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC30A7 gene [3]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Brain; Breast; Cervix; Embryo; Liver; Lung; Mesenchymal; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the SLC30A7 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 7.

        IRF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC30A7 gene [1]

TF Protein Name

 Interferon regulatory factor 1 Transcription Factor Info

Tissue

 Blood; Bone marrow; Pancreatic ductal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Interferon regulatory factor 1 (IRF1) can directly bind to the SLC30A7 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 7.

TF Superclass4: Other all-alpha-helical DNA-binding domains

      Class4.1: High-mobility group domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SOX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC30A7 gene in colorectal cancer condition [15]

TF Protein Name

 Transcription factor SOX-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor SOX-2 (SOX2) has been reported to activate the transcription of SLC30A7 gene in colorectal cancer condition, which leads to an increased expression of the drug transporter Zinc transporter 7.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        RBPJ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC30A7 gene in immortal lymphoblast cell lines condition [16]

TF Protein Name

 Recombining binding protein suppressor of hairless Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Recombining binding protein suppressor of hairless (RBPJ) has been reported to bind to the transcription of SLC30A7 gene in immortal lymphoblast cell lines condition, which leads to an affected expression of the drug transporter Zinc transporter 7.

        RELA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC30A7 gene in fibrosarcoma condition [17]

TF Protein Name

 Transcription factor p65 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor p65 (RELA) has been reported to activate the transcription of SLC30A7 gene in fibrosarcoma condition, which leads to an increased expression of the drug transporter Zinc transporter 7.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        SMAD3 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC30A7 gene in health condition [18]

TF Protein Name

 Mothers against decapentaplegic homolog 3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 3 (SMAD3) has been reported to activate the transcription of SLC30A7 gene in health condition, which leads to an increased expression of the drug transporter Zinc transporter 7.

       Transcriptional Phenomenon2

 Binding to SLC30A7 gene in health condition [19]

TF Protein Name

 Mothers against decapentaplegic homolog 3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Mothers against decapentaplegic homolog 3 (SMAD3) has been reported to bind to the transcription of SLC30A7 gene in health condition, which leads to an affected expression of the drug transporter Zinc transporter 7.

        SMAD4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC30A7 gene in health condition [18]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of SLC30A7 gene in health condition, which leads to an increased expression of the drug transporter Zinc transporter 7.

TF Superclass10: Yet undefined DNA-binding domains

      Class10.1: Other factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GTF2B 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC30A7 gene [11]

TF Protein Name

 Transcription initiation factor IIB Transcription Factor Info

Tissue

 Cervix; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription initiation factor IIB (GTF2B) can directly bind to the SLC30A7 gene, which in turn affects the expression or function of the drug transporter Zinc transporter 7.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-357. (ID:ENSG00000162695)
2 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
3 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
4 SLC30A7 has anti-oxidant stress effects in high glucose-induced apoptosis via the NFE2L2/HMOX1 signal transduction pathway. Diabetes Res Clin Pract. 2021 Feb;172:108445.
5 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
6 Epigenetically coordinated GATA2 binding is necessary for endothelium-specific endomucin expression. EMBO J. 2011;30(13):2582-95.
7 Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
8 Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
9 Over-expression of ZnT7 increases insulin synthesis and secretion in pancreatic beta-cells by promoting insulin gene transcription. Exp Cell Res. 2010 Oct 1;316(16):2630-43.
10 Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 2005;122(6):947-56.
11 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
12 Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family. Genes Dev. 2007;21(15):1882-94.
13 An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell. 2011;147(1):132-46.
14 Elucidation of the ELK1 target gene network reveals a role in the coordinate regulation of core components of the gene regulation machinery. Genome Res. 2009;19(11):1963-73.
15 ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers. OMICS. 2010;14(4):369-84.
16 Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth. Proc Natl Acad Sci U S A. 2011;108(36):14902-7.
17 Modulation of gene expression regulated by the transcription factor NF-B/RelA. J Biol Chem. 2014;289(17):11927-11944.
18 Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev Biol. 2011;357(2):492-504.
19 Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling. Mol Cell Biol. 2009;29(1):172-86.

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