Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID DTD0276 Transporter Info
Gene Name SLC30A7
Transporter Name Zinc transporter 7
Gene ID
148867
UniProt ID
Q8NEW0
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Chemical Compound

  DT Modulation1

 Cisplatin results in decreased susceptibility to Cisplatin which results in increased expression of SLC30A7 mRNA [23]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation1

 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with ochratoxin A co-treated with Zinc results in decreased expression of SLC30A7 mRNA [11]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc results in increased expression of SLC30A7 mRNA [11]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 SLC30A7 protein results in increased transport of Zinc [33]

Regulation Mechanism

 Transcription Factor Info

  7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC30A7 mRNA [17]

Regulation Mechanism

 Transcription Factor Info

  abrine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 abrine results in increased expression of SLC30A7 mRNA [18]

Regulation Mechanism

 Transcription Factor Info

  aristolochic acid I

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 aristolochic acid I results in decreased expression of SLC30A7 mRNA [20]

Regulation Mechanism

 Transcription Factor Info

  CGP 52608

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 CGP 52608 promotes the reaction RORA protein binds to SLC30A7 gene [22]

Regulation Mechanism

 Transcription Factor Info

  chloropicrin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 chloropicrin results in increased expression of SLC30A7 mRNA [13]

Regulation Mechanism

 Transcription Factor Info

  Diethylstilbestrol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Diethylstilbestrol results in increased expression of SLC30A7 mRNA [24]

Regulation Mechanism

 Transcription Factor Info

  Glucose

            4 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 SLC30A7 protein affects the reaction MIR200C mRNA affects the reaction Glucose results in increased cleavage of CASP1 protein [25]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 SLC30A7 protein affects the reaction MIR200C mRNA affects the reaction Glucose results in increased cleavage of GSDMD protein [25]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 SLC30A7 protein affects the reaction MIR200C mRNA affects the reaction Glucose results in increased secretion of IL18 protein [25]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation4

 SLC30A7 protein affects the reaction MIR200C mRNA affects the reaction Glucose results in increased secretion of IL1B protein [25]

Regulation Mechanism

 Transcription Factor Info

  Manganese

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 manganese chloride results in increased abundance of Manganese which results in increased expression of SLC30A7 mRNA [21]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC30A7 mRNA [21]

Regulation Mechanism

 Transcription Factor Info

  manganese chloride

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 manganese chloride results in increased abundance of Manganese which results in increased expression of SLC30A7 mRNA [21]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC30A7 mRNA [21]

Regulation Mechanism

 Transcription Factor Info

  Methyl Methanesulfonate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Methyl Methanesulfonate results in decreased expression of SLC30A7 mRNA [26]

Regulation Mechanism

 Transcription Factor Info

  N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine

            4 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with ochratoxin A co-treated with Zinc results in decreased expression of SLC30A7 mRNA [11]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc results in increased expression of SLC30A7 mRNA [11]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction ochratoxin A results in decreased expression of SLC30A7 mRNA [11]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation4

 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SLC30A7 mRNA [28]

Regulation Mechanism

 Transcription Factor Info

  sodium arsenite

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC30A7 mRNA [21]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 sodium arsenite results in increased abundance of Arsenic which results in increased expression of SLC30A7 mRNA [21]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 sodium arsenite results in increased expression of SLC30A7 mRNA [30]

Regulation Mechanism

 Transcription Factor Info

  triphenyl phosphate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 triphenyl phosphate affects the expression of SLC30A7 mRNA [31]

Regulation Mechanism

 Transcription Factor Info

  Valproic Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Valproic Acid results in decreased methylation of SLC30A7 gene [32]

Regulation Mechanism

 Transcription Factor Info

  zinc chloride

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 zinc chloride results in decreased expression of SLC30A7 mRNA [1]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 zinc chloride results in increased expression of SLC30A7 mRNA [1]

Regulation Mechanism

 Transcription Factor Info

Mycotoxins

  Aflatoxin B1

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Aflatoxin B1 results in decreased methylation of SLC30A7 gene [19]

Regulation Mechanism

 Transcription Factor Info

  ochratoxin A

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with ochratoxin A co-treated with Zinc results in decreased expression of SLC30A7 mRNA [11]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction ochratoxin A results in decreased expression of SLC30A7 mRNA [11]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 ochratoxin A results in decreased expression of SLC30A7 mRNA [11]

Regulation Mechanism

 Transcription Factor Info

Carcinogen

  Arsenic

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC30A7 mRNA [21]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 sodium arsenite results in increased abundance of Arsenic which results in increased expression of SLC30A7 mRNA [21]

Regulation Mechanism

 Transcription Factor Info

  Nickel

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Nickel results in increased expression of SLC30A7 mRNA [27]

Regulation Mechanism

 Transcription Factor Info

Approved Drug

  Acetaminophen

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Acetaminophen inhibits the expression of SLC30A7 [2]

  Zidovudine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Zidovudine increases the expression of SLC30A7 [3]

  Vorinostat

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Vorinostat inhibits the expression of SLC30A7 [4]

  Doxorubicin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Doxorubicin inhibits the expression of SLC30A7 [5]

  Ivermectin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Ivermectin inhibits the expression of SLC30A7 [6]

  Cyclosporine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cyclosporine increases the expression of SLC30A7 [7]

  Cisplatin

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cisplatin inhibits the expression of SLC30A7 [8]

Drug Marketed but not Approved by US FDA

  Zinc chloride

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Zinc chloride inhibits the expression of SLC30A7 [1]

Drug in Phase 2 Trial

  Colforsin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Colforsin inhibits the expression of SLC30A7 [9]

Drug in Phase 1 Trial

  Dihydrotestosterone

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Dihydrotestosterone increases the expression of SLC30A7 [15]

Investigative Drug

  Metribolone

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Metribolone increases the expression of SLC30A7 [9]

Natural Product

  Tobacco Smoke Pollution

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Tobacco Smoke Pollution increases the expression of SLC30A7 [16]

  Resveratrol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Plant Extracts co-treated with Resveratrol results in increased expression of SLC30A7 mRNA [29]

Regulation Mechanism

 Transcription Factor Info

Traditional Medicine

  Jinfukang

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Jinfukang inhibits the expression of SLC30A7 [14]

Plant Extract

  Grape Seed Proanthocyanidins

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Grape Seed Proanthocyanidins increases the expression of SLC30A7 [12]

Environmental toxicant

  Zinc

            4 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Zinc inhibits the expression of SLC30A7 [10]

Acute Toxic Substance

  Ochratoxin A

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Ochratoxin A inhibits the expression of SLC30A7 [11]

  Chloropicrin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Chloropicrin increases the expression of SLC30A7 [13]
References
1 Increased level of exogenous zinc induces cytotoxicity and up-regulates the expression of the ZnT-1 zinc transporter gene in pancreatic cancer cells. J Nutr Biochem. 2011 Jan;22(1):79-88.
2 Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
3 Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23.
4 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
5 Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
6 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975.
7 Integrative "-Omics" Analysis in Primary Human Hepatocytes Unravels Persistent Mechanisms of Cyclosporine A-Induced Cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
8 Low Doses of Cisplatin Induce Gene Alterations, Cell Cycle Arrest, and Apoptosis in Human Promyelocytic Leukemia Cells. Biomark Insights. 2016 Aug 24;11:113-21.
9 Identification of genes targeted by the androgen and PKA signaling pathways in prostate cancer cells. Oncogene. 2006 Nov 23;25(55):7311-23.
10 Profiling of zinc-altered gene expression in human prostate normal vs. cancer cells: a time course study. J Nutr Biochem. 2009 Dec;20(12):1000-12.
11 Intracellular zinc stores protect the intestinal epithelium from Ochratoxin A toxicity. Toxicol In Vitro. 2009 Dec;23(8):1516-21.
12 Dietary catechins and procyanidins modulate zinc homeostasis in human HepG2 cells. J Nutr Biochem. 2011 Feb;22(2):153-63.
13 Transcriptomic Analysis of Human Primary Bronchial Epithelial Cells after Chloropicrin Treatment. Chem Res Toxicol. 2015 Oct 19;28(10):1926-35.
14 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
15 LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
16 Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model. Arch Toxicol. 2021 May;95(5):1739-1761.
17 Early whole-genome transcriptional response induced by benzo[a]pyrene diol epoxide in a normal human cell line. Genomics. 2009;93(4):332-42.
18 Integration of transcriptomics, proteomics and metabolomics data to reveal the biological mechanisms of abrin injury in human lung epithelial cells. Toxicol Lett. 2019;312:1-10.
19 Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma. Toxicology. 2016 Mar 28;350-352:31-9.
20 Integration of transcriptomic, proteomic and metabolomic data to reveal the biological mechanisms of AAI injury in renal epithelial cells. Toxicol In Vitro. 2021;70:105054.
21 Using transcriptomic signatures to elucidate individual and mixture effects of inorganic arsenic and manganese in human placental trophoblast HTR-8/SVneo cells. Toxicol Sci. 2025;203(2):216-226.
22 Identification of potential target genes of ROR-alpha in THP1 and HUVEC cell lines. Exp Cell Res. 2017;353(1):6-15.
23 Transcriptomic Landscape of Cisplatin-Resistant Neuroblastoma Cells. Cells. 2019;8(3).
24 Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023;485:153425.
25 MiR-200c-3p regulates pyroptosis by targeting SLC30A7 in diabetic retinopathy. Hum Exp Toxicol. 2022;41:9603271221099589.
26 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
27 Molecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response. J Allergy Clin Immunol. 2014;134(2):362-72.
28 Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study. Biochem Pharmacol. 2004;68(4):699-709.
29 One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease. Pharmacol Res. 2013;72:69-82.
30 High-Throughput Transcriptomics of Nontumorigenic Breast Cells Exposed to Environmentally Relevant Chemicals. Environ Health Perspect. 2024;132(4):47002.
31 Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60-69 Years of Age: Evidence from the China BAPE Study. Environ Health Perspect. 2023;131(4):47009.
32 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
33 Expression of ZnT and ZIP zinc transporters in the human RPE and their regulation by neurotrophic factors. Invest Ophthalmol Vis Sci. 2008;49(3):1221-31.

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