| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0165 | ||||
| Gene Name | SLC24A4 | ||||
| Protein Name | Sodium/potassium/calcium exchanger 4 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:5HXC_A Identity:31.405% Minimized Score:-192.179 kcal/mol Detail: Structure Info |
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| Synonyms | AI2A5; NCKX4; Na(+)/K(+)/Ca(2+)-exchange protein 4; SHEP6; SLC24A4 NCKX4; Solute carrier family 24 member 4 | ||||
| DT Family | Ca(2+):Cation Antiporter (CACA) Family ; | ||||
| Tissue Specificity | Expressed abundantly in all regions of thebrain, aorta, lung and thymus. Expressed at lower levels in thestomach and intestine. | ||||
| Function | This transporter transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) and Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. It may play a role in calcium transport during amelogenesis. | ||||
| Endogenous Substrate(s) | Ca2+; K+; Na+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Sodium/potassium/calcium exchanger 4 |
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(β) Cell Distribution Level of Sodium/potassium/calcium exchanger 4 |
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(γ) Organelle Distribution Level of Sodium/potassium/calcium exchanger 4 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Sodium/potassium/calcium exchanger 4 |
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(γ) Transcriptional Regulation of Sodium/potassium/calcium exchanger 4 |
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(δ) Epigenetic Regulation of Sodium/potassium/calcium exchanger 4 |
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(ε) Exogenous Modulation of Sodium/potassium/calcium exchanger 4 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Sodium/potassium/calcium exchanger 4 |
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(β) Disease-specific Protein Abundances of Sodium/potassium/calcium exchanger 4 |
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(γ) Species- and Tissue-specific DT Abundances |
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