Drug Transporter (DT) Information

General Information of DT
DT ID DTD0126
Gene Name SLC19A1
Protein Name Folate transporter 1
Gene ID
6573
UniProt ID
P41440
TCDB ID
2.A.48.1.1
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms CHMD; FLOT1; FOLT; IFC-1; IFC1; Intestinal folate carrier 1; Placental folate transporter; REFC; RFC; RFC1; Reduced folate carrier protein; SLC19A1; Solute carrier family 19 member 1
DT Family Reduced Folate Carrier (RFC) Family ;
Tissue Specificity Placenta, liver, and to a much smaller extent,in lung.
Function This transporter mediates the uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H(+)-pump.
Disease(s) Malignant pleural mesothelioma [ICD-11:2C26.0]
Peripheral T-cell lymphoma [ICD-11:2A90.C]
Vitamin deficiency [ICD-11:5B55-5B7Z]
Endogenous Substrate(s) Folate derivatives
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Folate transporter 1
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Folate transporter 1
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Folate transporter 1
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Folate transporter 1
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Folate transporter 1
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Folate transporter 1
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Folate transporter 1
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Folate transporter 1
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Folate transporter 1
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           4 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Folic acid
 Approved Drug Info Vitamin deficiency 5B55-5B7Z [1]
Methotrexate
 Approved Drug Info Leukemia 2A60-2B33 [1]
Pemetrexed
 Approved Drug Info Malignant pleural mesothelioma 2C26.0 [1]
Pralatrexate
 Approved Drug Info Breast cancer 2C60-2C6Z [2]

Drug-DT Affinity Assessed by Cell Line

 Approved Drug

 Click to Show/Hide the Full List of Drug:           6 Drugs in Total
Drug Name Highest Status Detail Cell Line Affinity Ref
Pemetrexed Approved Drug Info Human liver cancer cells (HepG2)-FLOT1 Km =0.2 microM [2]
Pemetrexed Approved Drug Info Human liver cancer cells (HepG2)-FLOT1 Km =0.2 microM [2]
Pemetrexed Approved Drug Info Human liver cancer cells (HepG2)-FLOT1 Km =0.2 microM [2]
Pemetrexed Approved Drug Info Human liver cancer cells (HepG2)-FLOT1 Km =0.2 microM [2]
Pemetrexed Approved Drug Info Human liver cancer cells (HepG2)-FLOT1 Km =0.2 microM [2]
Pemetrexed Approved Drug Info Human liver cancer cells (HepG2)-FLOT1 Km =0.2 microM [2]
References
1 Biology of the major facilitative folate transporters SLC19A1 and SLC46A1. Curr Top Membr. 2014;73:175-204.
2 Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance. Drug Resist Updat. 2012 Aug;15(4):183-210.

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