Detail Information of DT Wildtype Structure
| General Information of Drug Transporter (DT) | ||||||
|---|---|---|---|---|---|---|
| DT ID | DTD0126 Transporter Info | |||||
| Gene Name | SLC19A1 | |||||
| Transporter Name | Folate transporter 1 | |||||
| Gene ID | ||||||
| UniProt ID | ||||||
| Experimental Structures of This DT | ||||||
| PDB ID | Scanning Method | Resolution | Expression System | Details | Ref | |
| 7TX6 | EM | 3.3 Å | Homo sapiens | [1] | ||
| Structure | ||||||
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| Corresponding chain | N.A. | |||||
| Sequence Length | N.A. | Mutation | No | |||
| 7TX7 | EM | 3.8 Å | Homo sapiens | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | N.A. | |||||
| Sequence Length | N.A. | Mutation | No | |||
| 7XPZ | EM | 3.4 Å | Spodoptera frugiperda | [2] | ||
| Structure | ||||||
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| Corresponding chain | A | |||||
| Sequence Length | 544 | Mutation | No | |||
| 7XQ0 | EM | 3 Å | Spodoptera frugiperda | [2] | ||
| Structure | ||||||
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| Corresponding chain | A | |||||
| Sequence Length | 544 | Mutation | No | |||
| 7XQ1 | EM | 3.4 Å | Spodoptera frugiperda | [2] | ||
| Structure | ||||||
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| Corresponding chain | A | |||||
| Sequence Length | 544 | Mutation | No | |||
| 7XQ2 | EM | 3.3 Å | Spodoptera frugiperda | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 544 | Mutation | No | |||
| 7XTK | EM | 2.89 Å | Homo sapiens | |||
| Structure | ||||||
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| Corresponding chain | A | |||||
| Sequence Length | 591 | Mutation | No | |||
| 8DEP | EM | 3.6 Å | Homo sapiens | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | N.A. | |||||
| Sequence Length | N.A. | Mutation | No | |||
| Modelled Structures of This DT | ||||||
| Click to Save PDB File in PDB Format | ||||||
| Detail Information of Modelled Structures | ||||||
| Method | multi-sequence alignment based machine learning | |||||
| AlphaFold Protein Structure Database | ||||||
| References | ||||||
| 1 | Methotrexate recognition by the human reduced folate carrier SLC19A1. Nature. 2022;609(7929):1056-1062. | |||||
| 2 | Recognition of cyclic dinucleotides and folates by human SLC19A1. Nature. 2022;612(7938):170-176. | |||||
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