Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0126 Transporter Info
Gene Name	SLC19A1
Transporter Name	Folate transporter 1
Gene ID	6573
UniProt ID	P41440

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Leucovorin inhibits the reaction SLC19A1 protein results in increased transport of Methotrexate			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Pemetrexed inhibits the reaction SLC19A1 protein results in increased transport of Methotrexate			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC19A1 exon mutant form results in increased susceptibility to Pemetrexed			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Leucovorin inhibits the reaction SLC19A1 protein results in increased transport of Methotrexate			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	lometrexol inhibits the reaction SLC19A1 protein results in increased transport of Methotrexate			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Methotrexate affects the expression of SLC19A1 mRNA			[57]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Methotrexate results in decreased activity of SLC19A1 protein which results in decreased uptake of Folic Acid			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Methotrexate results in decreased expression of SLC19A1 mRNA			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Methotrexate results in decreased expression of SLC19A1 protein			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Methotrexate results in decreased expression of SLC19A1 protein which results in decreased import of and results in decreased susceptibility to Methotrexate			[59]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	N-((5-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-6-yl)propyl)thiophen-2-yl)carbonyl)glutamic acid affects the reaction SLC19A1 protein results in increased transport of Methotrexate			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Pemetrexed inhibits the reaction SLC19A1 protein results in increased transport of Methotrexate			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	raltitrexed inhibits the reaction SLC19A1 protein results in increased transport of Methotrexate			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	SLC19A1 3' UTR polymorphism affects the transport of Methotrexate			[60]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	SLC19A1 exon mutant form results in decreased susceptibility to Methotrexate			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	SLC19A1 gene SNP affects the susceptibility to and affects the abundance of Methotrexate			[52]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	SLC19A1 gene SNP affects the susceptibility to Methotrexate			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	SLC19A1 gene SNP results in increased susceptibility to Methotrexate			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	SLC19A1 mRNA results in increased susceptibility to Methotrexate			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	SLC19A1 protein affects the susceptibility to Methotrexate			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	SLC19A1 protein results in increased susceptibility to Methotrexate			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	SLC19A1 protein results in increased transport of Methotrexate			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of SLC19A1 protein which results in decreased uptake of Folic Acid			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid results in decreased activity of SLC19A1 protein which results in decreased uptake of Folic Acid			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	5-methyltetrahydrofolate results in decreased activity of SLC19A1 protein which results in decreased uptake of Folic Acid			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Folic Acid affects the expression of SLC19A1 mRNA			[48]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Folic Acid deficiency results in decreased expression of SLC19A1 mRNA			[49]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Folic Acid deficiency results in decreased expression of SLC19A1 protein			[49]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Folic Acid deficiency results in increased expression of SLC19A1 mRNA			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Folic Acid results in decreased expression of SLC19A1 mRNA			[51]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Folic Acid results in decreased expression of SLC19A1 protein			[51]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Indomethacin results in decreased activity of SLC19A1 protein which results in decreased uptake of Folic Acid			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Methotrexate results in decreased activity of SLC19A1 protein which results in decreased uptake of Folic Acid			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	SLC19A1 gene SNP affects the abundance of Folic Acid			[52]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	SLC19A1 gene SNP affects the uptake of and affects the localization of Folic Acid			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	SLC19A1 protein results in increased uptake of Folic Acid			[54]
Regulation Mechanism				Transcription Factor Info
2-palmitoylglycerol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-palmitoylglycerol results in increased expression of SLC19A1 mRNA			[28]
Regulation Mechanism				Transcription Factor Info
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid results in decreased expression of SLC19A1 mRNA			[21]
Regulation Mechanism				Transcription Factor Info
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of SLC19A1 protein which results in decreased uptake of Folic Acid			[29]
Regulation Mechanism				Transcription Factor Info
4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid results in decreased activity of SLC19A1 protein which results in decreased uptake of Folic Acid			[29]
Regulation Mechanism				Transcription Factor Info
5-methyltetrahydrofolate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	5-methyltetrahydrofolate results in decreased activity of SLC19A1 protein which results in decreased uptake of Folic Acid			[29]
Regulation Mechanism				Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	abrine results in decreased expression of SLC19A1 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
afuresertib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	afuresertib results in decreased expression of SLC19A1 mRNA			[32]
Regulation Mechanism				Transcription Factor Info
aristolochic acid I	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	aristolochic acid I results in decreased expression of SLC19A1 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	aristolochic acid I results in decreased expression of SLC19A1 protein			[33]
Regulation Mechanism				Transcription Factor Info
ARV-825	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ARV-825 deficiency affects the reaction ARV-825 results in decreased expression of SLC19A1 protein			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ARV-825 results in decreased expression of SLC19A1 protein			[35]
Regulation Mechanism				Transcription Factor Info
Benzo(a)pyrene	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene affects the methylation of SLC19A1 promoter			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Benzo(a)pyrene results in increased methylation of SLC19A1 5' UTR			[36]
Regulation Mechanism				Transcription Factor Info
BGC638	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	BGC638 binds to and results in decreased activity of SLC19A1 protein			[37]
Regulation Mechanism				Transcription Factor Info
BGC945	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	BGC945 binds to and results in decreased activity of SLC19A1 protein			[37]
Regulation Mechanism				Transcription Factor Info
bisphenol A	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A results in decreased expression of SLC19A1 mRNA			[24]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bisphenol A results in decreased expression of SLC19A1 protein			[38]
Regulation Mechanism				Transcription Factor Info
Cadmium Chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in decreased expression of SLC19A1 mRNA			[39]
Regulation Mechanism				Transcription Factor Info
chromium hexavalent ion	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	zinc chromate results in increased abundance of chromium hexavalent ion which results in decreased expression of SLC19A1 mRNA			[41]
Regulation Mechanism				Transcription Factor Info
Cisplatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cisplatin co-treated with jinfukang results in increased expression of SLC19A1 mRNA			[22]
Regulation Mechanism				Transcription Factor Info
cobaltous chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cobaltous chloride results in decreased expression of SLC19A1 mRNA			[42]
Regulation Mechanism				Transcription Factor Info
Copper	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NSC 689534 binds to Copper which results in decreased expression of SLC19A1 mRNA			[43]
Regulation Mechanism				Transcription Factor Info
coumarin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	coumarin results in decreased phosphorylation of SLC19A1 protein			[40]
Regulation Mechanism				Transcription Factor Info
Diazinon	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diazinon results in increased methylation of SLC19A1 gene			[44]
Regulation Mechanism				Transcription Factor Info
Dichlorodiphenyl Dichloroethylene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dichlorodiphenyl Dichloroethylene results in increased expression of SLC19A1 mRNA			[45]
Regulation Mechanism				Transcription Factor Info
di-n-butylphosphoric acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	di-n-butylphosphoric acid affects the expression of SLC19A1 mRNA			[46]
Regulation Mechanism				Transcription Factor Info
entinostat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	entinostat results in decreased expression of SLC19A1 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
FR900359	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	FR900359 results in decreased phosphorylation of SLC19A1 protein			[55]
Regulation Mechanism				Transcription Factor Info
ICG 001	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ICG 001 results in decreased expression of SLC19A1 mRNA			[21]
Regulation Mechanism				Transcription Factor Info
Indomethacin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indomethacin results in decreased activity of SLC19A1 protein which results in decreased uptake of Folic Acid			[29]
Regulation Mechanism				Transcription Factor Info
lasiocarpine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CYP3A4 protein results in increased metabolism of lasiocarpine which results in decreased expression of SLC19A1 mRNA			[56]
Regulation Mechanism				Transcription Factor Info
lometrexol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	lometrexol inhibits the reaction SLC19A1 protein results in increased transport of Methotrexate			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC19A1 protein results in increased susceptibility to lometrexol			[2]
Regulation Mechanism				Transcription Factor Info
Methyl Methanesulfonate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methyl Methanesulfonate results in decreased expression of SLC19A1 mRNA			[20]
Regulation Mechanism				Transcription Factor Info
methylselenic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	methylselenic acid results in decreased expression of SLC19A1 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
Monocrotaline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CYP3A4 protein results in increased metabolism of Monocrotaline which results in decreased expression of SLC19A1 mRNA			[56]
Regulation Mechanism				Transcription Factor Info
N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC19A1 exon mutant form results in decreased susceptibility to N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine analog			[61]
Regulation Mechanism				Transcription Factor Info
Nicotine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nicotine results in decreased expression of SLC19A1 mRNA			[7]
Regulation Mechanism				Transcription Factor Info
NSC 689534	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NSC 689534 binds to Copper which results in decreased expression of SLC19A1 mRNA			[43]
Regulation Mechanism				Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in increased expression of SLC19A1 mRNA			[67]
Regulation Mechanism				Transcription Factor Info
OTX015	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	OTX015 deficiency inhibits the reaction OTX015 results in decreased expression of SLC19A1 protein			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	OTX015 results in decreased expression of SLC19A1 protein			[35]
Regulation Mechanism				Transcription Factor Info
Oxygen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oxygen deficiency results in decreased expression of SLC19A1 mRNA			[68]
Regulation Mechanism				Transcription Factor Info
Ozone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Air Pollutants results in increased abundance of Ozone which affects the expression of SLC19A1 mRNA			[69]
Regulation Mechanism				Transcription Factor Info
potassium chromate(VI)	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	potassium chromate(VI) results in increased expression of SLC19A1 mRNA			[70]
Regulation Mechanism				Transcription Factor Info
raltitrexed	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	raltitrexed inhibits the reaction SLC19A1 protein results in increased transport of Methotrexate			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC19A1 exon mutant form results in decreased susceptibility to raltitrexed			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC19A1 protein results in increased susceptibility to raltitrexed			[2]
Regulation Mechanism				Transcription Factor Info
Selenium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Selenium results in decreased expression of SLC19A1 mRNA			[17]
Regulation Mechanism				Transcription Factor Info
sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in decreased expression of SLC19A1 mRNA			[45]
Regulation Mechanism				Transcription Factor Info
Thiram	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Thiram results in decreased expression of SLC19A1 mRNA			[45]
Regulation Mechanism				Transcription Factor Info
trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	trichostatin A results in decreased expression of SLC19A1 mRNA			[23]
Regulation Mechanism				Transcription Factor Info
triphenyl phosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	triphenyl phosphate affects the expression of SLC19A1 mRNA			[46]
Regulation Mechanism				Transcription Factor Info
Valproic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid results in decreased expression of SLC19A1 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Valproic Acid results in increased methylation of SLC19A1 gene			[72]
Regulation Mechanism				Transcription Factor Info
zinc chromate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	zinc chromate results in increased abundance of chromium hexavalent ion which results in decreased expression of SLC19A1 mRNA			[41]
Regulation Mechanism				Transcription Factor Info
Mycotoxins
Aflatoxin B1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 results in increased methylation of SLC19A1 intron			[31]
Regulation Mechanism				Transcription Factor Info
Approved Drug
Leucovorin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Leucovorin inhibits the transportation of Methotrexate by SLC19A1			[1], [2]
Affected Drug/Substrate	Methotrexate	Modulation Type	Inhibition
DT Modulation2	Leucovorin inhibits the activity of SLC19A1			[3]
Pemetrexed	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pemetrexed inhibits the transportation of Methotrexate by SLC19A1			[1], [2]
Affected Drug/Substrate	Methotrexate	Modulation Type	Inhibition
DT Modulation2	Pemetrexed inhibits the activity of SLC19A1			[3]
Raltitrexed	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Raltitrexed inhibits the transportation of Methotrexate by SLC19A1			[2]
Affected Drug/Substrate	Methotrexate	Modulation Type	Inhibition
DT Modulation2	Raltitrexed inhibits the activity of SLC19A1			[3]
Methotrexate	20 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methotrexate inhibits the transportation of Methotrexate by SLC19A1			[1]
Affected Drug/Substrate	Methotrexate	Modulation Type	Inhibition
Decitabine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Decitabine increases the expression of SLC19A1			[4]
Irinotecan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Irinotecan inhibits the expression of SLC19A1			[5]
Copper Sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate inhibits the expression of SLC19A1			[6]
Atenolol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atenolol inhibits the expression of SLC19A1			[7]
Dronabinol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dronabinol inhibits the expression of SLC19A1			[7]
Nicotine polacrilex	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nicotine polacrilex inhibits the expression of SLC19A1			[7]
Hydrogen Peroxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hydrogen Peroxide affects the expression of SLC19A1			[8]
Carbamazepine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Carbamazepine affects the expression of SLC19A1			[9]
Diclofenac	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diclofenac affects the expression of SLC19A1			[9]
Urethane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Urethane inhibits the expression of SLC19A1			[10]
Acetaminophen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the expression of SLC19A1			[11]
Doxorubicin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Doxorubicin inhibits the expression of SLC19A1			[12]
Estradiol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol increases the expression of SLC19A1			[13]
Tretinoin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tretinoin inhibits the expression of SLC19A1			[14]
Folic Acid	15 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Folic acid modulates the activity of SLC19A1			[15]
Drug in Phase 3 Trial
Vitamin E	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vitamin E inhibits the expression of SLC19A1			[17]
Drug in Phase 2 Trial
Ethanol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethanol inhibits the expression of SLC19A1			[16]
Regulation Mechanism	via the inhibition of Transcription factor Sp1 (SP1)			Transcription Factor Info
Cell System	Human colon adenocarcinoma cells (Caco-2)
Genistein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Genistein increases the expression of SLC19A1			[19]
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol A inhibits the expression of SLC19A1			[24]
Drug in Phase 1/2 Trial
Talotrexin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Talotrexin inhibits the transportation of Methotrexate by SLC19A1			[2]
Affected Drug/Substrate	Methotrexate	Modulation Type	Inhibition
Drug in Phase 1 Trial
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trichostatin A inhibits the expression of SLC19A1			[23]
Drug in Preclinical Test
(+)-JQ1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	(+)-JQ1 inhibits the expression of SLC19A1			[27]
Patented Pharmaceutical Agent
ICG-001	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ICG-001 inhibits the expression of SLC19A1			[21]
Natural Product
Selenium nanoparticles	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Selenium nanoparticles inhibits the expression of SLC19A1			[17]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution inhibits the expression of SLC19A1			[26]
Caffeine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Caffeine affects the phosphorylation of SLC19A1 protein			[40]
Regulation Mechanism				Transcription Factor Info
Resveratrol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Plant Extracts co-treated with Resveratrol results in decreased expression of SLC19A1 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
Traditional Medicine
Jinfukang	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Jinfukang increases the expression of SLC19A1			[22]
Acute Toxic Substance
Formaldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Formaldehyde inhibits the expression of SLC19A1			[20]
Acrylamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acrylamide inhibits the expression of SLC19A1			[25]
Carcinogen
Ethyl Methanesulfonate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethyl Methanesulfonate inhibits the expression of SLC19A1			[20]
Arsenic	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arsenic affects the methylation of SLC19A1 gene			[34]
Regulation Mechanism				Transcription Factor Info
Herbicide
Atrazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atrazine inhibits the expression of SLC19A1			[18]

References
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