Drug Transporter (DT) Information

General Information of DT
DT ID DTD0109
Gene Name SLC16A5
Protein Name Monocarboxylate transporter 6
Gene ID
9121
UniProt ID
O15375
TCDB ID
2.A.1.13.11
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:7BP3_A

Identity:32.189%

Minimized Score:-871.511 kcal/mol

Detail: Structure Info

Synonyms Monocarboxylate transporter 5; MCT 5; MCT 6; Solute carrier family 16 member 5; SLC16A5; MCT5; MCT6
DT Family Major Facilitator Superfamily (MFS)
Monocarboxylate Transporter (MCT) Family
Tissue Specificity Highly expressed in kidney.
Function This Proton-linked monocarboxylate transporter catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.
Disease(s) Edema associated with congestive heart failure [ICD-11:BD10]
Hyperuricaemia [ICD-11:5C55.Y]
Endogenous Substrate(s) Monocarboxylates
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Monocarboxylate transporter 6
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Monocarboxylate transporter 6
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Monocarboxylate transporter 6
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Monocarboxylate transporter 6
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Monocarboxylate transporter 6
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Monocarboxylate transporter 6
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Monocarboxylate transporter 6
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

(γ) Outward/inward-facing Conformation
Outward/inward-facing Conformation (OIC)

(δ) Xenobiotics-regulated Structural Variability
Xenobiotics-regulated Structural Variability (XSV)

General Variability Data of This DT

(α) Genetic Polymorphisms of Monocarboxylate transporter 6
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Monocarboxylate transporter 6
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           3 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Bumetanide
 Approved Drug Info Edema associated with congestive heart failure BD10 [1]
Nateglinide
 Approved Drug Info Diabetes 5A10-5A14 [1]
Probenecid
 Approved Drug Info Hyperuricaemia 5C55.Y [1]
References
1 Quercetin, Morin, Luteolin, and Phloretin Are Dietary Flavonoid Inhibitors of Monocarboxylate Transporter 6. Mol Pharm. 2017 Sep 5;14(9):2930-2936.

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