Drug Transporter (DT) Information

General Information of DT
DT ID DTD0102
Gene Name SLC16A11
Protein Name Monocarboxylate transporter 11
Gene ID
162515
UniProt ID
Q8NCK7
TCDB ID
2.A.1.13.13
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:7BP3_A

Identity:34.474%

Minimized Score:-809.936 kcal/mol

Detail: Structure Info

Synonyms MCT 11; MCT11; SLC16A11; Solute carrier family 16 member 11
DT Family Major Facilitator Superfamily (MFS)
Monocarboxylate Transporter (MCT) Family
Tissue Specificity Expressed in liver, salivary gland andthyroid.
Function This transporter is proton-linked monocarboxylate transporter, and it catalyzes the transport of pyruvate across the plasma membrane.
Endogenous Substrate(s) Monocarboxylates
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Monocarboxylate transporter 11
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Monocarboxylate transporter 11
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Monocarboxylate transporter 11
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Monocarboxylate transporter 11
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Monocarboxylate transporter 11
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Monocarboxylate transporter 11
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Monocarboxylate transporter 11
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

(γ) Outward/inward-facing Conformation
Outward/inward-facing Conformation (OIC)

General Variability Data of This DT

(α) Genetic Polymorphisms of Monocarboxylate transporter 11
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Monocarboxylate transporter 11
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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