Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0102 Transporter Info
Gene Name SLC16A11
Transporter Name Monocarboxylate transporter 11
Gene ID
162515
UniProt ID
Q8NCK7

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        ATF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A11 gene [1]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-3 Transcription Factor Info

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLC16A11 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 11.

        CEBPB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A11 gene [2]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Breast; Colon; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC16A11 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 11.

        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A11 gene [3]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Blood; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC16A11 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 11.

        NFE2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A11 gene [1]

TF Protein Name

 Transcription factor NF-E2 45 kDa subunit Transcription Factor Info

Tissue

 Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor NF-E2 45 kDa subunit (NFE2) can directly bind to the SLC16A11 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 11.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        ASCL1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A11 gene [4]

TF Protein Name

 Achaete-scute homolog 1 Transcription Factor Info

Tissue

 Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Achaete-scute homolog 1 (ASCL1) can directly bind to the SLC16A11 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 11.

        MAX 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A11 gene [4]

TF Protein Name

 Protein max Transcription Factor Info

Tissue

 Blood; Bone marrow; Brain; Breast; Embryo; Liver; Lung; Uterus; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein max (MAX) can directly bind to the SLC16A11 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 11.

        TCF21 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC16A11 gene in Coronary Artery Disease [5]

TF Protein Name

 Transcription factor 21 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 21 (TCF21) has been reported to bind to the SLC16A11 gene in Coronary Artery Disease condition, which affects the expression or function of the drug transporter Monocarboxylate transporter 11.

        TCF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A11 gene [2]

TF Protein Name

 Transcription factor E2-alpha Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2-alpha (TCF3) can directly bind to the SLC16A11 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 11.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        NR2F2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A11 gene [1]

TF Protein Name

 COUP transcription factor 2 Transcription Factor Info

Tissue

 Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 COUP transcription factor 2 (NR2F2) can directly bind to the SLC16A11 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 11.

        PPARD 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLC16A11 gene in myofibroblasts condition [6]

TF Protein Name

 Peroxisome proliferator-activated receptor delta Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of SLC16A11 gene in myofibroblasts condition, which leads to a decreased expression of the drug transporter Monocarboxylate transporter 11.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GATA4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC16A11 gene in gastric cancer condition [7]

TF Protein Name

 Transcription factor GATA-4 Transcription Factor Info

Affected Drug/Substrate

 Metformin

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor GATA-4 (GATA4) has been reported to activate the transcription of SLC16A11 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 11.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 8 TF(s) Regulating This DT

        CTCF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A11 gene [3]

TF Protein Name

 Transcriptional repressor CTCF Transcription Factor Info

Tissue

 Brain

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCF (CTCF) can directly bind to the SLC16A11 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 11.

        KLF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A11 gene [4]

TF Protein Name

 Krueppel-like factor 4 Transcription Factor Info

Tissue

 Foreskin; Pancreatic ductal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 4 (KLF4) can directly bind to the SLC16A11 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 11.

        KLF5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A11 gene [3]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Tissue

 Embryo; Pancreatic ductal; Stomach

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 5 (KLF5) can directly bind to the SLC16A11 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 11.

        KLF9 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A11 gene [4]

TF Protein Name

 Krueppel-like factor 9 Transcription Factor Info

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 9 (KLF9) can directly bind to the SLC16A11 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 11.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A11 gene [1]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Bone marrow; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC16A11 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 11.

        ZBTB7A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A11 gene [2]

TF Protein Name

 Zinc finger and BTB domain-containing protein 7A Transcription Factor Info

Tissue

 Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLC16A11 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 11.

        ZNF263 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A11 gene [2]

TF Protein Name

 Zinc finger protein 263 Transcription Factor Info

Tissue

 Bone marrow; Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 263 (ZNF263) can directly bind to the SLC16A11 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 11.

        ZNF384 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A11 gene [3]

TF Protein Name

 Zinc finger protein 384 Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 384 (ZNF384) can directly bind to the SLC16A11 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 11.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        HNF1B 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A11 gene [1]

TF Protein Name

 Hepatocyte nuclear factor 1-beta Transcription Factor Info

Tissue

 Embryo; Pancreatic ductal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 1-beta (HNF1B) can directly bind to the SLC16A11 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 11.

        ZEB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A11 gene [2]

TF Protein Name

 Zinc finger E-box-binding homeobox 1 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger E-box-binding homeobox 1 (ZEB1) can directly bind to the SLC16A11 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 11.

      Class3.2: Paired box factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        PAX5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A11 gene [3]

TF Protein Name

 Paired box protein Pax-5 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Paired box protein Pax-5 (PAX5) can directly bind to the SLC16A11 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 11.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        E2F6 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A11 gene [3]

TF Protein Name

 Transcription factor E2F6 Transcription Factor Info

Tissue

 Embryo

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F6 (E2F6) can directly bind to the SLC16A11 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 11.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        ERG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A11 gene [4]

TF Protein Name

 Transcriptional regulator ERG Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional regulator ERG (ERG) can directly bind to the SLC16A11 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 11.

        FLI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A11 gene [4]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC16A11 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 11.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A11 gene [1]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the SLC16A11 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 11.

        SPI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A11 gene [4]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Tissue

 Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor PU.1 (SPI1) can directly bind to the SLC16A11 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 11.

      Class3.7: ARID domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        ARID3A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A11 gene [3]

TF Protein Name

 AT-rich interactive domain-containing protein 3A Transcription Factor Info

Tissue

 Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 AT-rich interactive domain-containing protein 3A (ARID3A) can directly bind to the SLC16A11 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 11.

        KDM5B 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A11 gene [2]

TF Protein Name

 Lysine-specific demethylase 5B Transcription Factor Info

Tissue

 Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Lysine-specific demethylase 5B (KDM5B) can directly bind to the SLC16A11 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 11.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        EBF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A11 gene [1]

TF Protein Name

 Transcription factor COE1 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor COE1 (EBF1) can directly bind to the SLC16A11 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 11.

      Class6.4: Runt domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        RUNX3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC16A11 gene [2]

TF Protein Name

 Runt-related transcription factor 3 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Runt-related transcription factor 3 (RUNX3) can directly bind to the SLC16A11 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 11.
References
1 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
3 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
4 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-401. (ID:ENSG00000174326)
5 Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. PLoS Genet. 2015;11(5):e1005202.
6 Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor. PLoS One. 2011;6(1):e16344.
7 Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.

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