Drug Transporter (DT) Information

General Information of DT
DT ID DTD0091
Gene Name SLC13A1
Protein Name Sodium/sulfate cotransporter 1
Gene ID
6561
UniProt ID
Q9BZW2
TCDB ID
2.A.47.1.16
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms NAS1; NASI1; NaSi-1; SLC13A1; Solute carrier family 13 member 1; Na(+)/sulfate cotransporter; hNaSi-1; Renal sodium/sulfate cotransporter
DT Family Divalent Anion:Na(+) Symporter (DASS) Family ;
Tissue Specificity Highly expressed in kidney; not detectable inthe other tissues tested.
Function This transporter sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney.
Endogenous Substrate(s) Na+; Sfulate; Thiosulfate; Selenium; Anions
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium/sulfate cotransporter 1
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium/sulfate cotransporter 1
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium/sulfate cotransporter 1
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Sodium/sulfate cotransporter 1
Microbiota Influence (MBI)

(β) Post-translational Modification of Sodium/sulfate cotransporter 1
Post-translational Modification (PTM)

(δ) Epigenetic Regulation of Sodium/sulfate cotransporter 1
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium/sulfate cotransporter 1
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium/sulfate cotransporter 1
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium/sulfate cotransporter 1
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Drug-DT Affinity Assessed by Cell Line

 Withdrawn, Discontinued or Preclinical Drug

 Click to Show/Hide the Full List of Drug:           7 Drugs in Total
Drug Name Highest Status Detail Cell Line Affinity Ref
Sulfate Investigative Drug Info Renal and intestinal epithelial cells Km =93 microM [1]
Sulfate Investigative Drug Info Renal and intestinal epithelial cells Km =93 microM [1]
Sulfate Investigative Drug Info Renal and intestinal epithelial cells Km =93 microM [1]
Sulfate Investigative Drug Info Renal and intestinal epithelial cells Km =93 microM [1]
Sulfate Investigative Drug Info Renal and intestinal epithelial cells Km =93 microM [1]
Sulfate Investigative Drug Info Renal and intestinal epithelial cells Km =93 microM [1]
Sulfate Investigative Drug Info Renal and intestinal epithelial cells Km =93 microM [1]
References
1 Na+-sulfate cotransporter SLC13A1. Pflugers Arch. 2014 Jan;466(1):131-7.

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