Detail Information of Epigenetic Regulations

General Information of Drug Transporter (DT)
DT ID DTD0091 Transporter Info
Gene Name SLC13A1
Transporter Name Sodium/sulfate cotransporter 1
Gene ID
6561
UniProt ID
Q9BZW2
Epigenetic Regulations of This DT (EGR)

Methylation

  Pancretic ductal adenocarcinoma

            2 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC13A1 in pancretic ductal adenocarcinoma [ 1 ]

Location

 5'UTR (cg05146599)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.05E+00 Statistic Test p-value:3.13E-02; Z-score:5.58E-01

Methylation in Case

 8.54E-01 (Median) Methylation in Control 8.14E-01 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC13A1 in pancretic ductal adenocarcinoma [ 1 ]

Location

 3'UTR (cg00928751)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.11E+00 Statistic Test p-value:6.47E-07; Z-score:-1.40E+00

Methylation in Case

 7.96E-01 (Median) Methylation in Control 8.81E-01 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Hepatocellular carcinoma

            4 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC13A1 in hepatocellular carcinoma [ 2 ]

Location

 TSS1500 (cg03564727)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.40E+00 Statistic Test p-value:2.27E-11; Z-score:-4.97E+00

Methylation in Case

 5.90E-01 (Median) Methylation in Control 8.26E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC13A1 in hepatocellular carcinoma [ 2 ]

Location

 TSS200 (cg00895997)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.33E+00 Statistic Test p-value:6.77E-06; Z-score:-1.79E+00

Methylation in Case

 3.66E-01 (Median) Methylation in Control 4.85E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of SLC13A1 in hepatocellular carcinoma [ 2 ]

Location

 1stExon (cg22024657)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.04E+00 Statistic Test p-value:9.76E-05; Z-score:-5.02E-01

Methylation in Case

 7.43E-01 (Median) Methylation in Control 7.70E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon4

 Methylation of SLC13A1 in hepatocellular carcinoma [ 2 ]

Location

 Body (cg03993154)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.11E+00 Statistic Test p-value:1.81E-02; Z-score:-3.79E-01

Methylation in Case

 1.15E-01 (Median) Methylation in Control 1.27E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Bladder cancer

            2 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC13A1 in bladder cancer [ 3 ]

Location

 TSS200 (cg00895997)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.57E+00 Statistic Test p-value:3.71E-08; Z-score:-1.37E+01

Methylation in Case

 4.35E-01 (Median) Methylation in Control 6.82E-01 (Median)

Studied Phenotype

 Bladder cancer[ ICD-11:2C94]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC13A1 in bladder cancer [ 3 ]

Location

 1stExon (cg22024657)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.10E+00 Statistic Test p-value:7.53E-04; Z-score:-6.48E+00

Methylation in Case

 8.16E-01 (Median) Methylation in Control 8.97E-01 (Median)

Studied Phenotype

 Bladder cancer[ ICD-11:2C94]

Experimental Material

 Patient tissue samples

  Lung adenocarcinoma

            2 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC13A1 in lung adenocarcinoma [ 4 ]

Location

 TSS200 (cg00895997)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.08E+00 Statistic Test p-value:3.07E-02; Z-score:-2.19E+00

Methylation in Case

 7.09E-01 (Median) Methylation in Control 7.64E-01 (Median)

Studied Phenotype

 Lung adenocarcinoma[ ICD-11:2C25.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC13A1 in lung adenocarcinoma [ 4 ]

Location

 Body (cg03993154)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.34E+00 Statistic Test p-value:1.55E-04; Z-score:3.42E+00

Methylation in Case

 1.73E-01 (Median) Methylation in Control 1.30E-01 (Median)

Studied Phenotype

 Lung adenocarcinoma[ ICD-11:2C25.0]

Experimental Material

 Patient tissue samples

  Papillary thyroid cancer

            2 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC13A1 in papillary thyroid cancer [ 5 ]

Location

 TSS200 (cg00895997)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.04E+00 Statistic Test p-value:1.59E-03; Z-score:-9.08E-01

Methylation in Case

 7.89E-01 (Median) Methylation in Control 8.23E-01 (Median)

Studied Phenotype

 Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC13A1 in papillary thyroid cancer [ 5 ]

Location

 Body (cg03993154)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.24E+00 Statistic Test p-value:1.77E-07; Z-score:-1.27E+00

Methylation in Case

 1.23E-01 (Median) Methylation in Control 1.52E-01 (Median)

Studied Phenotype

 Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

 Patient tissue samples

  Systemic lupus erythematosus

            1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC13A1 in systemic lupus erythematosus [ 6 ]

Location

 TSS200 (cg00895997)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.02E+00 Statistic Test p-value:1.67E-02; Z-score:-2.14E-01

Methylation in Case

 7.57E-01 (Median) Methylation in Control 7.74E-01 (Median)

Studied Phenotype

 Systemic lupus erythematosus[ ICD-11:4A40.0]

Experimental Material

 Patient tissue samples

  Atypical teratoid rhabdoid tumor

            2 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC13A1 in atypical teratoid rhabdoid tumor [ 7 ]

Location

 1stExon (cg22024657)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.30E+00 Statistic Test p-value:8.58E-17; Z-score:-2.52E+00

Methylation in Case

 6.88E-01 (Median) Methylation in Control 8.92E-01 (Median)

Studied Phenotype

 Atypical teratoid rhabdoid tumor[ ICD-11:2A00.1Y]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC13A1 in atypical teratoid rhabdoid tumor [ 7 ]

Location

 Body (cg03993154)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.01E+00 Statistic Test p-value:5.15E-04; Z-score:-7.25E-01

Methylation in Case

 9.42E-01 (Median) Methylation in Control 9.55E-01 (Median)

Studied Phenotype

 Atypical teratoid rhabdoid tumor[ ICD-11:2A00.1Y]

Experimental Material

 Patient tissue samples

  Breast cancer

            2 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC13A1 in breast cancer [ 8 ]

Location

 1stExon (cg22024657)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.04E+00 Statistic Test p-value:9.14E-05; Z-score:-1.10E+00

Methylation in Case

 8.25E-01 (Median) Methylation in Control 8.60E-01 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC13A1 in breast cancer [ 8 ]

Location

 Body (cg03993154)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.42E+00 Statistic Test p-value:5.08E-08; Z-score:1.96E+00

Methylation in Case

 1.16E-01 (Median) Methylation in Control 8.17E-02 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  HIV infection

            1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC13A1 in HIV infection [ 9 ]

Location

 Body (cg03993154)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.46E+00 Statistic Test p-value:1.59E-06; Z-score:2.27E+00

Methylation in Case

 1.96E-01 (Median) Methylation in Control 1.34E-01 (Median)

Studied Phenotype

 HIV infection[ ICD-11:1C62.Z]

Experimental Material

 Patient tissue samples

  Prostate cancer

            1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC13A1 in prostate cancer [ 10 ]

Location

 Body (cg14084826)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.35E+00 Statistic Test p-value:4.97E-02; Z-score:-3.85E+00

Methylation in Case

 5.91E-01 (Median) Methylation in Control 7.98E-01 (Median)

Studied Phenotype

 Prostate cancer[ ICD-11:2C82]

Experimental Material

 Patient tissue samples
References
1 Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling. Int J Cancer. 2014 Sep 1;135(5):1110-8.
2 Exploring genome-wide DNA methylation profiles altered in hepatocellular carcinoma using Infinium HumanMethylation 450 BeadChips. Epigenetics. 2013 Jan;8(1):34-43.
3 DNA Methylation Dynamics in Urological Tumors.
4 DNA methylation analysis of lung adenocarcinoma and adjacent non-tumor tissues
5 Prognostic Classifier Based on Genome-Wide DNA Methylation Profiling in Well-Differentiated Thyroid Tumors. J Clin Endocrinol Metab. 2017 Nov 1;102(11):4089-4099.
6 Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+ T-cell populations. PLoS Genet. 2013;9(8):e1003678.
7 Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes. Cancer Cell. 2016 Mar 14;29(3):379-393.
8 Genome-wide Scan for Methylation Profiles in Breast Cancer
9 HIV-1 Infection Accelerates Age According to the Epigenetic Clock. J Infect Dis. 2015 Nov 15;212(10):1563-73.
10 Reducing the risk of false discovery enabling identification of biologically significant genome-wide methylation status using the HumanMethylation450 array. BMC Genomics. 2014 Jan 22;15:51.

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