Drug Transporter (DT) Information

General Information of DT
DT ID DTD0063
Gene Name ABCD1
Protein Name Adrenoleukodystrophy protein
Gene ID
215
UniProt ID
P33897
TCDB ID
3.A.1.203.3
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms ABC42; ABCD1 ALD; ALD; ALDP; AMN; ATP-binding cassette sub-family D member 1; Adrenoleukodystrophy protein
DT Family ATP-Binding Cassette (ABC) Superfamily ;
Function This transporter plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis.
Endogenous Substrate(s) Long-chain fatty acids
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Adrenoleukodystrophy protein
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Adrenoleukodystrophy protein
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Adrenoleukodystrophy protein
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Adrenoleukodystrophy protein
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Adrenoleukodystrophy protein
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Adrenoleukodystrophy protein
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Adrenoleukodystrophy protein
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(γ) Outward/inward-facing Conformation
Outward/inward-facing Conformation (OIC)

General Variability Data of This DT

(α) Genetic Polymorphisms of Adrenoleukodystrophy protein
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Adrenoleukodystrophy protein
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Endogenous Metabolites (EMs) Handled by This DT

 Endogenous Metabolites (EMs)

 Click to Show/Hide the Full List of EMs:           7 EMs in Total
EM Name PubChem CID Detail Experimental Material Ref
Cholic acid
221493
EM Info Identified using Abcd1 Knockout mice [1]
Eicosapentaenoic acid
446284
EM Info Identified using Abcd1 Knockout mice [1]
Glycocholic acid
10140
EM Info Identified using Abcd1 Knockout mice [1]
Hexadecanedioic acid
10459
EM Info Identified using Abcd1 Knockout mice [1]
N-hexanoic acid
8892
EM Info Identified using Abcd1 Knockout mice [1]
Purine
1044
EM Info Identified using Abcd1 Knockout mice [1]
Trihydroxycoprostane
160520
EM Info Identified using Abcd1 Knockout mice [1]
References
1 Altered glycolipid and glycerophospholipid signaling drive inflammatory cascades in adrenomyeloneuropathy. Hum Mol Genet. 2015 Dec 15;24(24):6861-76.

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