Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0063 Transporter Info
Gene Name	ABCD1
Transporter Name	Adrenoleukodystrophy protein
Gene ID	215
UniProt ID	P33897

Post-Translational Modification of This DT
Overview ofABCD1 Modification Sites with Functional and Structural Information
Sequence	M P V L S R P R P W R G N T L K R T A V L L A L A A Y G A H K V Y P L V R Q C L A P A R G L Q A P A G E P T Q E A S G V A A A K A G M N R V F L Q R L L W L L R L L F P R V L C R E T G L L A L H S A A L V S R T F L S V Y V A R L D G R L A R C I V R K D P R A F G W Q L L Q W L L I A L P A T F V N S A I R Y L E G Q L A L S F R S R L V A H A Y R L Y F S Q Q T Y Y R V S N M D G R L R N P D Q S L T E D V V A F A A S V A H L Y S N L T K P L L D V A V T S Y T L L R A A R S R G A G T A W P S A I A G L V V F L T A N V L R A F S P K F G E L V A E E A R R K G E L R Y M H S R V V A N S E E I A F Y G G H E V E L A L L Q R S Y Q D L A S Q I N L I L L E R L W Y V M L E Q F L M K Y V W S A S G L L M V A V P I I T A T G Y S E S D A E A V K K A A L E K K E E E L V S E R T E A F T I A R N L L T A A A D A I E R I M S S Y K E V T E L A G Y T A R V H E M F Q V F E D V Q R C H F K R P R E L E D A Q A G S G T I G R S G V R V E G P L K I R G Q V V D V E Q G I I C E N I P I V T P S G E V V V A S L N I R V E E G M H L L I T G P N G C G K S S L F R I L G G L W P T Y G G V L Y K P P P Q R M F Y I P Q R P Y M S V G S L R D Q V I Y P D S V E D M Q R K G Y S E Q D L E A I L D V V H L H H I L Q R E G G W E A M C D W K D V L S G G E K Q R I G M A R M F Y H R P K Y A L L D E C T S A V S I D V E G K I F Q A A K D A G I A L L S I T H R P S L W K Y H T H L L Q F D G E G G W K F E K L D S A A R L S L T E E K Q R L E Q Q L A G I P K M Q R R L Q E L C Q I L G E A V A P A H V P A P S P Q G P G G L Q G A S T
PTM type	X-Acetylation X-N-glycosylation X-Oxidation X-Phosphorylation X-Phosphorylation X-Ubiquitination X: Amino Acid

Acetylation
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCD1			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	696
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ABCD1 Lysine 696 has the potential to affect its expression or activity.
N-glycosylation
Asparagine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCD1			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	214
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at ABCD1 Asparagine 214 has the potential to affect its expression or activity.
Oxidation
Cystine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCD1			[3]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	511
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at ABCD1 Cystine 511 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCD1			[3]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	631
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at ABCD1 Cystine 631 has the potential to affect its expression or activity.
Phosphorylation
Serine	13 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCD1			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	58
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCD1 Serine 58 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCD1			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	262
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCD1 Serine 262 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	284
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCD1 Serine 284 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCD1			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	358
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCD1 Serine 358 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCD1			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	360
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCD1 Serine 360 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ABCD1			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	404
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCD1 Serine 404 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ABCD1			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	447
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCD1 Serine 447 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ABCD1			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	453
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCD1 Serine 453 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence ABCD1			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	515
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCD1 Serine 515 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence ABCD1			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	656
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCD1 Serine 656 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence ABCD1			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	662
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCD1 Serine 662 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence ABCD1			[11], [12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	733
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCD1 Serine 733 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence ABCD1			[5], [10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	744
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCD1 Serine 744 has the potential to affect its expression or activity.
Threonine	7 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCD1			[13], [14]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	105
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCD1 Threonine 105 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCD1			[7], [15]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	393
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCD1 Threonine 393 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCD1			[16]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	410
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCD1 Threonine 410 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCD1			[16]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	416
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCD1 Threonine 416 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCD1			[17], [18]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	449
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCD1 Threonine 449 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ABCD1			[10]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	658
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCD1 Threonine 658 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ABCD1			[10]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	745
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCD1 Threonine 745 has the potential to affect its expression or activity.
Tyrosine	9 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCD1			[14]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	110
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCD1 Tyrosine 110 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[6]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	180
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCD1 Tyrosine 180 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[6]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	181
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCD1 Tyrosine 181 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[6]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	281
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCD1 Tyrosine 281 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCD1			[2]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	337
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCD1 Tyrosine 337 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ABCD1			[2]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	357
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCD1 Tyrosine 357 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ABCD1			[7]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	406
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCD1 Tyrosine 406 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ABCD1			[16]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	415
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCD1 Tyrosine 415 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence ABCD1			[13], [14]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	666
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCD1 Tyrosine 666 has the potential to affect its expression or activity.
Ubiquitination
Lysine	15 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCD1			[13], [19]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	64
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCD1 Lysine 64 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCD1			[13], [20]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	264
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCD1 Lysine 264 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCD1			[20]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	367
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCD1 Lysine 367 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCD1			[21], [22]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	407
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCD1 Lysine 407 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCD1			[23], [24]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	462
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCD1 Lysine 462 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ABCD1			[13]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	513
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCD1 Lysine 513 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ABCD1			[13], [22]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	533
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCD1 Lysine 533 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ABCD1			[13], [19]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	569
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCD1 Lysine 569 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence ABCD1			[24]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	602
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCD1 Lysine 602 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence ABCD1			[21], [24]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	610
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCD1 Lysine 610 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence ABCD1			[13], [19]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	648
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCD1 Lysine 648 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence ABCD1			[24]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	680
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCD1 Lysine 680 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence ABCD1			[21], [24]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	683
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCD1 Lysine 683 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence ABCD1			[24]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	696
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCD1 Lysine 696 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence ABCD1			[13], [24]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	708
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCD1 Lysine 708 has the potential to affect its expression or activity.

References
1	Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response. Mol Cell. 2015 Sep 3;59(5):867-81.
2	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: ABCD1_HUMAN)
3	A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell. 2020 Mar 5;180(5):968-983.e24.
4	Offline pentafluorophenyl (PFP)-RP prefractionation as an alternative to high-pH RP for comprehensive LC-MS/MS proteomics and phosphoproteomics. Anal Bioanal Chem. 2017 Jul;409(19):4615-4625.
5	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
6	15 years of PhosphoSitePlus?: integrating post-translationally modified sites, disease variants and isoforms. Nucleic Acids Res. 2019;47(D1):D433-D441.
7	Radiosensitization of human leukemic HL-60 cells by ATR kinase inhibitor (VE-821): phosphoproteomic analysis. Int J Mol Sci. 2014 Jul 7;15(7):12007-26.
8	Proteogenomic integration reveals therapeutic targets in breast cancer xenografts. Nat Commun. 2017 Mar 28;8:14864.
9	Isoelectric point-based fractionation by HiRIEF coupled to LC-MS allows for in-depth quantitative analysis of the phosphoproteome. Sci Rep. 2017 Jul 3;7(1):4513.
10	Feasibility of large-scale phosphoproteomics with higher energy collisional dissociation fragmentation. J Proteome Res. 2010 Dec 3;9(12):6786-94.
11	UniProt: a worldwide hub of protein knowledge. Nucleic Acids Res. 2019 Jan 8;47(D1):D506-D515.
12	Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors. Mol Syst Biol. 2018 Mar 5;14(3):e7858.
13	Systematic functional prioritization of protein posttranslational modifications. Cell. 2012 Jul 20;150(2):413-25.
14	The Plk1-dependent phosphoproteome of the early mitotic spindle. Mol Cell Proteomics. 2011 Jan;10(1):M110.004457.
15	iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics. Mol Cell Proteomics. 2012 Jun;11(6):M111.014423.
16	Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3.
17	In situ sample processing approach (iSPA) for comprehensive quantitative phosphoproteome analysis. J Proteome Res. 2014 Sep 5;13(9):3896-904.
18	Global phosphoproteome analysis of human bone marrow reveals predictive phosphorylation markers for the treatment of acute myeloid leukemia with quizartinib. Leukemia. 2014 Mar;28(3):716-9.
19	Global identification of modular cullin-RING ligase substrates. Cell. 2011 Oct 14;147(2):459-74.
20	Highly Multiplexed Quantitative Mass Spectrometry Analysis of Ubiquitylomes. Cell Syst. 2016 Oct 26;3(4):395-403.e4.
21	Integrative Analysis of Proteome and Ubiquitylome Reveals Unique Features of Lysosomal and Endocytic Pathways in Gefitinib-Resistant Non-Small Cell Lung Cancer Cells. Proteomics. 2018 Aug;18(15):e1700388.
22	Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. J Biol Chem. 2011 Dec 2;286(48):41530-41538.
23	Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling. Mol Cell. 2020 Mar 5;77(5):1124-1142.e10.
24	UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites. Nat Struct Mol Biol. 2018 Jul;25(7):631-640.

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Detail Information of Post-Translational Modifications

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