Drug Transporter (DT) Information

General Information of DT
DT ID DTD0061
Gene Name ABCC8
Protein Name Sulfonylurea receptor 1
Gene ID
6833
UniProt ID
Q09428
TCDB ID
3.A.1.208.4
3D Structure

Modelled DT Structure

Method:loop building

Template PDB:6C3O_E

Identity:100%

Minimized Score:-3149.585 kcal/mol

Detail: Structure Info

Synonyms ATP-binding cassette sub-family C member 8; ABCC8; ABC36; HRINS; SUR; SUR1; HHF1; TNDM2; SUR1delta2
DT Family ATP-Binding Cassette (ABC) Superfamily
Drug Conjugate Transporter (DCT) Family (ABCC)
Function This transporter is subunit of the beta-cell ATP-sensitive potassium channel (KATP) and it regulator of ATP-sensitive K+ channels and insulin release.
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sulfonylurea receptor 1
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sulfonylurea receptor 1
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sulfonylurea receptor 1
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Sulfonylurea receptor 1
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Sulfonylurea receptor 1
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sulfonylurea receptor 1
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sulfonylurea receptor 1
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(α) Mutation-induced Structural Variation
Mutation-induced Structural Variation (MSV)

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sulfonylurea receptor 1
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sulfonylurea receptor 1
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Tolbutamide
 Approved Drug Info Non insulin dependent diabetes 5A11 [1]
References
1 ABCC8 and ABCC9: ABC transporters that regulate K+ channels. Pflugers Arch. 2007 Feb;453(5):703-18.

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