Detail Information of DT Wildtype Structure
| General Information of Drug Transporter (DT) | ||||||
|---|---|---|---|---|---|---|
| DT ID | DTD0061 Transporter Info | |||||
| Gene Name | ABCC8 | |||||
| Transporter Name | Sulfonylurea receptor 1 | |||||
| Gene ID | ||||||
| UniProt ID | ||||||
| Modelled Structures of This DT | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Detail Information of Structural Model | ||||||
| Method | Loop building | |||||
| Template PDB | 6C3O_E | Identity | 100% | |||
| Performance | Minimized Score | -3149.585 kcal/mol | ||||
| Ramachandra Favored | Medium |
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| QMEANBrane Quality | Medium |
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| Ramachandran Plot |
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| Click to Save Ramachandran Plot in PNG Format | ||||||
| Ramz Z Score | -1.31 ±0.19 | |||||
| Residues in Favored Region | 1511 | Ramachandran favored | 95.75% | |||
| Number of Outliers | 14 | Ramachandran outliers | 0.89% | |||
| Local Quality |
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| Click to Save Local Quality Plot in PNG Format | ||||||
| QMEANBrane Score | 0.76 | |||||
| AlphaFold Protein Structure Database | ||||||
| SWISS-MODEL Database | ||||||
| Experimental Structures of This DT | ||||||
| PDB ID | Scanning Method | Resolution | Expression System | Details | Ref | |
| 6C3P | EM | 5.6 Å | Homo sapiens | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | E/F/G/H | |||||
| Sequence Length | 1-1581 | Mutation | No | |||
| 7S5V | EM | 3.3 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | E | |||||
| Sequence Length | 1581 | Mutation | No | |||
| 7S5X | EM | 3.7 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | E | |||||
| Sequence Length | 1582 | Mutation | No | |||
| 7S5Y | EM | 3.9 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | E | |||||
| Sequence Length | 1582 | Mutation | No | |||
| 7S5Z | EM | 3.9 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | E | |||||
| Sequence Length | 1582 | Mutation | No | |||
| 7S60 | EM | 3.7 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | E | |||||
| Sequence Length | 1582 | Mutation | No | |||
| 7S61 | EM | 4 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | E | |||||
| Sequence Length | 1582 | Mutation | No | |||
| References | ||||||
| 1 | Molecular structure of human KATP in complex with ATP and ADP. Elife. 2017 Dec 29;6:e32481. | |||||
| 2 | Molecular structure of an open human K(ATP) channel. Proc Natl Acad Sci U S A. 2021;118(48). | |||||
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