Drug Transporter (DT) Information

General Information of DT
DT ID DTD0540
Gene Name ATP12A
Protein Name Potassium-transporting ATPase alpha chain 2
Gene ID
479
UniProt ID
P54707
TCDB ID
3.A.3.1.13
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:4XE5_A

Identity:64.902%

Minimized Score:-2634.284 kcal/mol

Detail: Structure Info

Synonyms Non-gastric H(+)/K(+) ATPase subunit alpha; Proton pump; ATP12A; ATP1AL1
DT Family P-type ATPase (P-ATPase) Superfamily ;
Tissue Specificity Found in skin and kidney. Detected in prostate basal cells (at protein level). Expression is increased in benign prostate hyperplasia and tumor tissues (at protein level).
Function This transporter responsible for potassium absorption in various tissues, and catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane.
Endogenous Substrate(s) Na+, K+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Potassium-transporting ATPase alpha chain 2
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Potassium-transporting ATPase alpha chain 2
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Potassium-transporting ATPase alpha chain 2
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Potassium-transporting ATPase alpha chain 2
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Potassium-transporting ATPase alpha chain 2
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Potassium-transporting ATPase alpha chain 2
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Potassium-transporting ATPase alpha chain 2
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

(δ) Xenobiotics-regulated Structural Variability
Xenobiotics-regulated Structural Variability (XSV)

General Variability Data of This DT

(α) Genetic Polymorphisms of Potassium-transporting ATPase alpha chain 2
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Potassium-transporting ATPase alpha chain 2
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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