Detail Information of Epigenetic Regulations

General Information of Drug Transporter (DT)
DT ID DTD0540 Transporter Info
Gene Name ATP12A
Transporter Name Potassium-transporting ATPase alpha chain 2
Gene ID
479
UniProt ID
P54707
Epigenetic Regulations of This DT (EGR)

Methylation

  Bladder cancer

            4 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of ATP12A in bladder cancer [ 1 ]

Location

 TSS1500 (cg24762359)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.73E+00 Statistic Test p-value:2.41E-10; Z-score:-2.58E+01

Methylation in Case

 1.09E-01 (Median) Methylation in Control 1.89E-01 (Median)

Studied Phenotype

 Bladder cancer[ ICD-11:2C94]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of ATP12A in bladder cancer [ 1 ]

Location

 TSS1500 (cg16634108)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.59E+00 Statistic Test p-value:1.44E-06; Z-score:-5.13E+00

Methylation in Case

 8.99E-02 (Median) Methylation in Control 1.43E-01 (Median)

Studied Phenotype

 Bladder cancer[ ICD-11:2C94]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of ATP12A in bladder cancer [ 1 ]

Location

 Body (cg13337662)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.30E+00 Statistic Test p-value:1.72E-05; Z-score:-4.01E+00

Methylation in Case

 3.80E-01 (Median) Methylation in Control 4.94E-01 (Median)

Studied Phenotype

 Bladder cancer[ ICD-11:2C94]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon4

 Methylation of ATP12A in bladder cancer [ 1 ]

Location

 Body (cg14118062)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-3.29E+00 Statistic Test p-value:1.81E-05; Z-score:-5.91E+00

Methylation in Case

 7.47E-02 (Median) Methylation in Control 2.45E-01 (Median)

Studied Phenotype

 Bladder cancer[ ICD-11:2C94]

Experimental Material

 Patient tissue samples

  Breast cancer

            3 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of ATP12A in breast cancer [ 2 ]

Location

 TSS1500 (cg16634108)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.42E+00 Statistic Test p-value:2.79E-10; Z-score:-1.33E+00

Methylation in Case

 9.51E-02 (Median) Methylation in Control 1.35E-01 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of ATP12A in breast cancer [ 2 ]

Location

 TSS1500 (cg24762359)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.30E+00 Statistic Test p-value:6.28E-09; Z-score:-1.17E+00

Methylation in Case

 1.43E-01 (Median) Methylation in Control 1.86E-01 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of ATP12A in breast cancer [ 2 ]

Location

 Body (cg05719720)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.07E+00 Statistic Test p-value:1.49E-02; Z-score:3.75E-01

Methylation in Case

 9.91E-02 (Median) Methylation in Control 9.29E-02 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Colon cancer

            1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of ATP12A in colon adenocarcinoma [ 3 ]

Location

 TSS1500 (cg26870192)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:2.31E+00 Statistic Test p-value:1.09E-03; Z-score:5.73E+00

Methylation in Case

 2.25E-01 (Median) Methylation in Control 9.71E-02 (Median)

Studied Phenotype

 Colon cancer[ ICD-11:2B90]

Experimental Material

 Patient tissue samples

  Hepatocellular carcinoma

            6 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of ATP12A in hepatocellular carcinoma [ 4 ]

Location

 TSS1500 (cg24762359)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.04E+00 Statistic Test p-value:8.81E-03; Z-score:2.55E-01

Methylation in Case

 2.45E-01 (Median) Methylation in Control 2.36E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of ATP12A in hepatocellular carcinoma [ 4 ]

Location

 TSS200 (cg23781398)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.13E+00 Statistic Test p-value:2.67E-03; Z-score:3.57E-01

Methylation in Case

 1.35E-01 (Median) Methylation in Control 1.19E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of ATP12A in hepatocellular carcinoma [ 4 ]

Location

 Body (cg02792538)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:2.26E+00 Statistic Test p-value:9.22E-18; Z-score:4.43E+00

Methylation in Case

 3.86E-01 (Median) Methylation in Control 1.71E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon4

 Methylation of ATP12A in hepatocellular carcinoma [ 4 ]

Location

 Body (cg05719720)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:2.06E+00 Statistic Test p-value:6.37E-09; Z-score:2.64E+00

Methylation in Case

 1.51E-01 (Median) Methylation in Control 7.36E-02 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon5

 Methylation of ATP12A in hepatocellular carcinoma [ 4 ]

Location

 Body (cg13337662)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.30E+00 Statistic Test p-value:5.22E-08; Z-score:-1.61E+00

Methylation in Case

 4.45E-01 (Median) Methylation in Control 5.76E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon6

 Methylation of ATP12A in hepatocellular carcinoma [ 4 ]

Location

 Body (cg14118062)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-2.43E+00 Statistic Test p-value:9.68E-08; Z-score:-2.48E+00

Methylation in Case

 1.00E-01 (Median) Methylation in Control 2.44E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Lung adenocarcinoma

            3 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of ATP12A in lung adenocarcinoma [ 5 ]

Location

 TSS1500 (cg24762359)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.48E+00 Statistic Test p-value:9.54E-05; Z-score:-2.42E+00

Methylation in Case

 2.01E-01 (Median) Methylation in Control 2.98E-01 (Median)

Studied Phenotype

 Lung adenocarcinoma[ ICD-11:2C25.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of ATP12A in lung adenocarcinoma [ 5 ]

Location

 TSS1500 (cg16634108)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.46E+00 Statistic Test p-value:2.11E-04; Z-score:-2.77E+00

Methylation in Case

 1.63E-01 (Median) Methylation in Control 2.38E-01 (Median)

Studied Phenotype

 Lung adenocarcinoma[ ICD-11:2C25.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of ATP12A in lung adenocarcinoma [ 5 ]

Location

 Body (cg14118062)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.29E+00 Statistic Test p-value:4.73E-03; Z-score:-1.08E+00

Methylation in Case

 1.50E-01 (Median) Methylation in Control 1.94E-01 (Median)

Studied Phenotype

 Lung adenocarcinoma[ ICD-11:2C25.0]

Experimental Material

 Patient tissue samples

  Pancretic ductal adenocarcinoma

            3 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of ATP12A in pancretic ductal adenocarcinoma [ 6 ]

Location

 TSS1500 (cg15423862)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.04E+00 Statistic Test p-value:3.86E-03; Z-score:9.99E-01

Methylation in Case

 8.98E-01 (Median) Methylation in Control 8.66E-01 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of ATP12A in pancretic ductal adenocarcinoma [ 6 ]

Location

 Body (cg26503701)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.05E+00 Statistic Test p-value:3.28E-02; Z-score:1.04E+00

Methylation in Case

 8.36E-01 (Median) Methylation in Control 7.94E-01 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of ATP12A in pancretic ductal adenocarcinoma [ 6 ]

Location

 3'UTR (cg02287371)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.14E+00 Statistic Test p-value:2.96E-02; Z-score:-5.28E-01

Methylation in Case

 2.71E-01 (Median) Methylation in Control 3.10E-01 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Prostate cancer

            3 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of ATP12A in prostate cancer [ 7 ]

Location

 1stExon (cg06123346)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.61E+00 Statistic Test p-value:2.58E-02; Z-score:-5.65E+00

Methylation in Case

 3.65E-01 (Median) Methylation in Control 5.89E-01 (Median)

Studied Phenotype

 Prostate cancer[ ICD-11:2C82]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of ATP12A in prostate cancer [ 7 ]

Location

 Body (cg03488613)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.04E+00 Statistic Test p-value:3.80E-02; Z-score:5.85E+00

Methylation in Case

 9.45E-01 (Median) Methylation in Control 9.09E-01 (Median)

Studied Phenotype

 Prostate cancer[ ICD-11:2C82]

Experimental Material

 Patient tissue samples

  Renal cell carcinoma

            1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of ATP12A in clear cell renal cell carcinoma [ 8 ]

Location

 Body (cg05719720)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.15E+00 Statistic Test p-value:7.02E-03; Z-score:5.94E-01

Methylation in Case

 7.61E-02 (Median) Methylation in Control 6.64E-02 (Median)

Studied Phenotype

 Renal cell carcinoma[ ICD-11:2C90]

Experimental Material

 Patient tissue samples

  Colorectal cancer

            4 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of ATP12A in colorectal cancer [ 9 ]

Location

 Body (cg05719720)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:2.09E+00 Statistic Test p-value:1.94E-08; Z-score:3.93E+00

Methylation in Case

 9.90E-02 (Median) Methylation in Control 4.74E-02 (Median)

Studied Phenotype

 Colorectal cancer[ ICD-11:2B91]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of ATP12A in colorectal cancer [ 9 ]

Location

 Body (cg14118062)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.57E+00 Statistic Test p-value:4.62E-05; Z-score:-1.11E+00

Methylation in Case

 1.48E-01 (Median) Methylation in Control 2.32E-01 (Median)

Studied Phenotype

 Colorectal cancer[ ICD-11:2B91]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of ATP12A in colorectal cancer [ 9 ]

Location

 Body (cg13337662)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.05E+00 Statistic Test p-value:9.48E-03; Z-score:-5.37E-01

Methylation in Case

 6.61E-01 (Median) Methylation in Control 6.93E-01 (Median)

Studied Phenotype

 Colorectal cancer[ ICD-11:2B91]

Experimental Material

 Patient tissue samples

  Papillary thyroid cancer

            1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of ATP12A in papillary thyroid cancer [ 10 ]

Location

 Body (cg14118062)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.84E+00 Statistic Test p-value:4.01E-07; Z-score:-1.80E+00

Methylation in Case

 1.41E-01 (Median) Methylation in Control 2.58E-01 (Median)

Studied Phenotype

 Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

 Patient tissue samples
References
1 DNA Methylation Dynamics in Urological Tumors.
2 Genome-wide Scan for Methylation Profiles in Breast Cancer
3 Genome-scale analysis of DNA methylation in colorectal cancer using Infinium HumanMethylation450 BeadChips. Epigenetics. 2013 Sep;8(9):921-34.
4 Exploring genome-wide DNA methylation profiles altered in hepatocellular carcinoma using Infinium HumanMethylation 450 BeadChips. Epigenetics. 2013 Jan;8(1):34-43.
5 DNA methylation analysis of lung adenocarcinoma and adjacent non-tumor tissues
6 Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling. Int J Cancer. 2014 Sep 1;135(5):1110-8.
7 Reducing the risk of false discovery enabling identification of biologically significant genome-wide methylation status using the HumanMethylation450 array. BMC Genomics. 2014 Jan 22;15:51.
8 A CpG-methylation-based assay to predict survival in clear cell renal cell carcinoma. Nat Commun. 2015 Oct 30;6:8699.
9 Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer. Gastroenterology. 2014 Aug;147(2):418-29.e8.
10 Prognostic Classifier Based on Genome-Wide DNA Methylation Profiling in Well-Differentiated Thyroid Tumors. J Clin Endocrinol Metab. 2017 Nov 1;102(11):4089-4099.

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