| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0535 | ||||
| Gene Name | CACNB2 | ||||
| Protein Name | Voltage-dependent L-type calcium channel beta-2 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:6JPA_C Identity:72.951% Minimized Score:-919.207 kcal/mol Detail: Structure Info |
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| Synonyms | CAB2; CACNB2; CACNLB2; CAVB2; Calcium channel voltage-dependent subunit beta 2; Lambert-Eaton myasthenic syndrome antigen B; MYSB; Voltage-dependent L-type calcium channel subunit beta-2 | ||||
| DT Family | Ca(2+) Channel Auxiliary Subunit Beta Types 1-4 (CCA-Beta) Family ; | ||||
| Tissue Specificity | Expressed in all tissues. | ||||
| Function | The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. | ||||
| Endogenous Substrate(s) | Ca2+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Voltage-dependent L-type calcium channel beta-2 |
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(β) Cell Distribution Level of Voltage-dependent L-type calcium channel beta-2 |
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(γ) Organelle Distribution Level of Voltage-dependent L-type calcium channel beta-2 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Voltage-dependent L-type calcium channel beta-2 |
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(γ) Transcriptional Regulation of Voltage-dependent L-type calcium channel beta-2 |
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(δ) Epigenetic Regulation of Voltage-dependent L-type calcium channel beta-2 |
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(ε) Exogenous Modulation of Voltage-dependent L-type calcium channel beta-2 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Voltage-dependent L-type calcium channel beta-2 |
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(β) Disease-specific Protein Abundances of Voltage-dependent L-type calcium channel beta-2 |
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(γ) Species- and Tissue-specific DT Abundances |
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