Drug Transporter (DT) Information

General Information of DT
DT ID DTD0527
Gene Name SCN4A
Protein Name Voltage-gated sodium channel alpha Nav1.4
Gene ID
6329
UniProt ID
P35499
TCDB ID
1.A.1.10.4
3D Structure

Crystal Structure

Crystallisation Method:EM

PDB ID:6AGF

Corresponding Chain:A

Sequence Length:1-1836

Detail: Struture Info

Synonyms CMS16; HOKPP2; HYKPP; HYPP; NAC1A; Na(V)1.4; Nav1.4; SCN4A; SkM1; Sodium channel protein skeletal muscle subunit alpha; Sodium channel protein type IV subunit alpha; Sodium channel protein type 4 subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.4
DT Family Voltage-Gated Ion Channel (VIC) Superfamily ;
Function This pore-forming subunit of a voltage-gated transporter complex mediates the transport of Na(+) ions pass in accordance with their electrochemical gradient. Alternates between resting, activated and inactivated states. Required for normal muscle fiber excitability, normal muscle contraction and relaxation cycles, and constant muscle strength in the presence of fluctuating K(+) levels.
Endogenous Substrate(s) Na+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Voltage-gated sodium channel alpha Nav1.4
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Voltage-gated sodium channel alpha Nav1.4
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Voltage-gated sodium channel alpha Nav1.4
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Voltage-gated sodium channel alpha Nav1.4
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Voltage-gated sodium channel alpha Nav1.4
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Voltage-gated sodium channel alpha Nav1.4
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Voltage-gated sodium channel alpha Nav1.4
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

(δ) Xenobiotics-regulated Structural Variability
Xenobiotics-regulated Structural Variability (XSV)

General Variability Data of This DT

(α) Genetic Polymorphisms of Voltage-gated sodium channel alpha Nav1.4
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Voltage-gated sodium channel alpha Nav1.4
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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