Modelled DT Structure
Method:homology modeling
Template PDB:4XPT_A
Identity:47.426%
Minimized Score:-1499.232 kcal/mol
Detail: Structure Info
Drug Transporter (DT) Information
| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0459 | ||||
| Gene Name | SLC6A7 | ||||
| Protein Name | Sodium-dependent proline transporter | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
|
||||
| Synonyms | PROT; SLC6A7; Solute carrier family 6 member 7 | ||||
| DT Family | Neurotransmitter:Sodium Symporter (NSS) Family ; | ||||
| Tissue Specificity | Brain. | ||||
| Function | This transporter terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic terminals. | ||||
| Endogenous Substrate(s) | Na+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
|
Regulatory Variability Data of This DT (VARIDT 4.0) |
|||||
|
(α) Tissue Distribution Level of Sodium-dependent proline transporter |
|||||
|
(β) Cell Distribution Level of Sodium-dependent proline transporter |
|||||
|
(γ) Organelle Distribution Level of Sodium-dependent proline transporter |
|||||
|
Regulatory Variability Data of This DT |
|||||
|
(α) Microbiota Influence of Sodium-dependent proline transporter |
|||||
|
(β) Post-translational Modification of Sodium-dependent proline transporter |
|||||
|
(γ) Transcriptional Regulation of Sodium-dependent proline transporter |
|||||
|
(δ) Epigenetic Regulation of Sodium-dependent proline transporter |
|||||
|
(ε) Exogenous Modulation of Sodium-dependent proline transporter |
|||||
|
Structural Variability Data of This DT |
|||||
|
(β) Inter-species Structural Differences |
|||||
|
(γ) Outward/inward-facing Conformation |
|||||
|
(δ) Xenobiotics-regulated Structural Variability |
|||||
|
General Variability Data of This DT |
|||||
|
(α) Genetic Polymorphisms of Sodium-dependent proline transporter |
|||||
|
(β) Disease-specific Protein Abundances of Sodium-dependent proline transporter |
|||||
|
(γ) Species- and Tissue-specific DT Abundances |
|||||
| Molecular Transporting Profile of This DT | |||||
|
Full List of Drug(s) Transported by This DT |
|||||
|
Approved Drug |
Click to Show/Hide the Full List of Drug: 1 Drugs in Total | ||||
| Drug Name | Highest Status | Detail | Indication | ICD 11 | Ref |
|
L-proline
|
Approved | Drug Info | Dietary shortage | 5B7Z | [1] |
| References | |||||
| 1 | A new association between polymorphisms of the SLC6A7 gene in the chromosome 5q31-32 region and asthma. J Hum Genet. 2010 Jun;55(6):358-65. | ||||
If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.