Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0459 Transporter Info
Gene Name	SLC6A7
Transporter Name	Sodium-dependent proline transporter
Gene ID	6534
UniProt ID	Q99884

Post-Translational Modification of This DT
Overview ofSLC6A7 Modification Sites with Functional and Structural Information
Sequence	M K K L Q G A H L R K P V T P D L L M T P S D Q G D V D L D V D F A A H R G N W T G K L D F L L S C I G Y C V G L G N V W R F P Y R A Y T N G G G A F L V P Y F L M L A I C G I P L F F L E L S L G Q F S S L G P L A V W K I S P L F K G A G A A M L L I V G L V A I Y Y N M I I A Y V L F Y L F A S L T S D L P W E H C G N W W N T E L C L E H R V S K D G N G A L P L N L T C T V S P S E E Y W S R Y V L H I Q G S Q G I G S P G E I R W N L C L C L L L A W V I V F L C I L K G V K S S G K V V Y F T A T F P Y L I L L M L L V R G V T L P G A W K G I Q F Y L T P Q F H H L L S S K V W I E A A L Q I F Y S L G V G F G G L L T F A S Y N T F H Q N I Y R D T F I V T L G N A I T S I L A G F A I F S V L G Y M S Q E L G V P V D Q V A K A G P G L A F V V Y P Q A M T M L P L S P F W S F L F F F M L L T L G L D S Q F A F L E T I V T A V T D E F P Y Y L R P K K A V F S G L I C V A M Y L M G L I L T T D G G M Y W L V L L D D Y S A S F G L M V V V I T T C L A V T R V Y G I Q R F C R D I H M M L G F K P G L Y F R A C W L F L S P A T L L A L M V Y S I V K Y Q P S E Y G S Y R F P P W A E L L G I L M G L L S C L M I P A G M L V A V L R E E G S L W E R L Q Q A S R P A M D W G P S L E E N R T G M Y V A T L A G S Q S P K P L M V H M R K Y G G I T S F E N T A I E V D R E I A E E E E S M M
PTM type	X-N-glycosylation X-Phosphorylation X-Phosphorylation X: Amino Acid

N-glycosylation
Asparagine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC6A7			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	182
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC6A7 Asparagine 182 has the potential to affect its expression or activity.
Phosphorylation
Serine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	582
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A7 Serine 582 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC6A7			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	600
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A7 Serine 600 has the potential to affect its expression or activity.
Threonine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC6A7			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	248
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A7 Threonine 248 has the potential to affect its expression or activity.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: SC6A7_HUMAN)
2	BioMuta and BioXpress: mutation and expression knowledgebases for cancer biomarker discovery. Nucleic Acids Res. 2018;46(D1):D1128-D1136.
3	Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates. Cell Metab. 2015 Nov 3;22(5):922-35.
4	The phosphoproteome of human Jurkat T cell clones upon costimulation with anti-CD3/anti-CD28 antibodies. J Proteomics. 2016 Jan 10;131:190-198.
5	iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics. Mol Cell Proteomics. 2012 Jun;11(6):M111.014423.

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Detail Information of Post-Translational Modifications

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