Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0459 Transporter Info
Gene Name SLC6A7
Transporter Name Sodium-dependent proline transporter
Gene ID
6534
UniProt ID
Q99884

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        CEBPB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC6A7 gene [1]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Blood; Breast; Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC6A7 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent proline transporter.

        JUN 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC6A7 gene in K562 cells [2]

TF Protein Name

 Transcription factor Jun Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor Jun (JUN) has been reported to bind to the transcription of SLC6A7 gene in K562 cells, which leads to an affected expression of the drug transporter Sodium-dependent proline transporter.

      Class1.2: Basic helix-loop-helix factors

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        TCF21 

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       Transcriptional Phenomenon1

 Direct binding to SLC6A7 gene [3]

TF Protein Name

 Transcription factor 21 Transcription Factor Info

Tissue

 Coronary artery

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor 21 (TCF21) can directly bind to the SLC6A7 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent proline transporter.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.3: C2H2 zinc finger factors

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        BCL6 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC6A7 gene in CMLJURLMK1 condition [4]

TF Protein Name

 B-cell lymphoma 6 protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 B-cell lymphoma 6 protein (BCL6) has been reported to activate the transcription of SLC6A7 gene in CMLJURLMK1 condition, which leads to an increased expression of the drug transporter Sodium-dependent proline transporter.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC6A7 gene [5]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Bone marrow; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC6A7 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent proline transporter.

        ZNF263 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC6A7 gene [1]

TF Protein Name

 Zinc finger protein 263 Transcription Factor Info

Tissue

 Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 263 (ZNF263) can directly bind to the SLC6A7 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent proline transporter.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

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        HNF1B 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC6A7 gene in renal cysts condition [6]

TF Protein Name

 Hepatocyte nuclear factor 1-beta Transcription Factor Info

Studied Phenotype

 Renal cysts [ICD11: GB80]

Tissue

 Kidney

Related DT Changes

 Up regulating

Experimental Material

 Zebrafish TgPT::EGFP)

Detailed Description

 Hepatocyte nuclear factor 1-beta (HNF1B) has been reported to activate the transcription of SLC6A7 gene in renal cysts condition, which leads to an increased expression of the drug transporter Sodium-dependent proline transporter.

        PBX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC6A7 gene [1]

TF Protein Name

 Pre-B-cell leukemia transcription factor 1 Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Pre-B-cell leukemia transcription factor 1 (PBX1) can directly bind to the SLC6A7 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent proline transporter.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        E2F6 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC6A7 gene [7]

TF Protein Name

 Transcription factor E2F6 Transcription Factor Info

Tissue

 Embryo

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F6 (E2F6) can directly bind to the SLC6A7 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent proline transporter.

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC6A7 gene [5]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Tissue

 Embryo; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC6A7 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent proline transporter.

      Class3.5: Tryptophan cluster factors

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        SPI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC6A7 gene [3]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Tissue

 Blood; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor PU.1 (SPI1) can directly bind to the SLC6A7 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent proline transporter.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

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        RBPJ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC6A7 gene in immortal lymphoblast cell lines (LCLs) condition [8]

TF Protein Name

 Recombining binding protein suppressor of hairless Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Recombining binding protein suppressor of hairless (RBPJ) has been reported to bind to the transcription of SLC6A7 gene in immortal lymphoblast cell lines (LCLs) condition, which leads to an affected expression of the drug transporter Sodium-dependent proline transporter.

TF Superclass10: Yet undefined DNA-binding domains

      Class10.5: GTF2I domain factors

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        GTF2I 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC6A7 gene [7]

TF Protein Name

 General transcription factor II-I Transcription Factor Info

Tissue

 Foreskin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 General transcription factor II-I (GTF2I) can directly bind to the SLC6A7 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent proline transporter.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-139. (ID:ENSG00000011083)
2 c-Jun binding site identification in K562 cells. J Genet Genomics. 2011;38(6):235-42.
3 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
4 The transcriptional regulator BCL6 participates in the secondary gene regulatory response to vitamin D. Biochim Biophys Acta. 2015;1849(3):300-8.
5 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
6 Transcriptional profiling of the zebrafish proximal tubule. Am J Physiol Renal Physiol. 2019 Aug 1;317(2):F478-F488.
7 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
8 Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth. Proc Natl Acad Sci U S A. 2011;108(36):14902-7.

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