Crystal Structure
Crystallisation Method:EM
Corresponding Chain:A
Sequence Length:1-630
Detail: Struture Info
Drug Transporter (DT) Information
| General Information of DT | |||||
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| DT ID | DTD0456 | ||||
| Gene Name | SLC6A4 | ||||
| Protein Name | Sodium-dependent serotonin transporter | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
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| Synonyms | 5-HTT; 5-HTTLPR; 5HT transporter; 5HTT; HTT; OCD1; SERT; SERT1; SLC6A4; Solute carrier family 6 member 4; hSERT; hSERT | ||||
| DT Family | Neurotransmitter:Sodium Symporter (NSS) Family ; | ||||
| Tissue Specificity | Expressed in platelets (at protein level). | ||||
| Function | This transporter involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization in the central nervous system. Terminates the action of serotonin and recycles it in a sodium-dependent manner. | ||||
| Endogenous Substrate(s) | Cl-; Na+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Sodium-dependent serotonin transporter |
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(β) Cell Distribution Level of Sodium-dependent serotonin transporter |
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(γ) Organelle Distribution Level of Sodium-dependent serotonin transporter |
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Regulatory Variability Data of This DT |
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(α) Microbiota Influence of Sodium-dependent serotonin transporter |
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(β) Post-translational Modification of Sodium-dependent serotonin transporter |
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(γ) Transcriptional Regulation of Sodium-dependent serotonin transporter |
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(δ) Epigenetic Regulation of Sodium-dependent serotonin transporter |
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(ε) Exogenous Modulation of Sodium-dependent serotonin transporter |
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Structural Variability Data of This DT |
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(α) Mutation-induced Structural Variation |
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(β) Inter-species Structural Differences |
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(γ) Outward/inward-facing Conformation |
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(δ) Xenobiotics-regulated Structural Variability |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Sodium-dependent serotonin transporter |
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(β) Disease-specific Protein Abundances of Sodium-dependent serotonin transporter |
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(γ) Species- and Tissue-specific DT Abundances |
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| Molecular Transporting Profile of This DT | |||||
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Full List of Drug(s) Transported by This DT |
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Withdrawn, Discontinued or Preclinical Drug |
Click to Show/Hide the Full List of Drug: 1 Drugs in Total | ||||
| Drug Name | Highest Status | Detail | Indication | ICD 11 | Ref |
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Oxypertine
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Preclinical | Drug Info | Schizophrenia | 6A20 | [1] |
| References | |||||
| 1 | Serotonin transporter gene and treatment of alcoholism. | ||||
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