Drug Transporter (DT) Information

General Information of DT
DT ID DTD0426
Gene Name SLC5A6
Protein Name Sodium-dependent multivitamin transporter
Gene ID
8884
UniProt ID
Q9Y289
TCDB ID
2.A.21.5.7
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms Na(+)-dependent multivitamin transporter; SLC5A6; SMVT; Solute carrier family 5 member 6
DT Family Solute:Sodium Symporter (SSS) Family ;
Function This dodium-dependent transporter is mediates the transport of pantothenate, biotin and lipoate.
Endogenous Substrate(s) Na+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium-dependent multivitamin transporter
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium-dependent multivitamin transporter
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium-dependent multivitamin transporter
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Sodium-dependent multivitamin transporter
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Sodium-dependent multivitamin transporter
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sodium-dependent multivitamin transporter
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium-dependent multivitamin transporter
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium-dependent multivitamin transporter
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium-dependent multivitamin transporter
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Gabapentin enacarbil
 Approved Drug Info Postherpetic neuralgia 1E91.5 [1]
References
1 Clinical pharmacokinetic drug interaction studies of gabapentin enacarbil, a novel transported prodrug of gabapentin, with naproxen and cimetidine. Br J Clin Pharmacol. 2010 May;69(5):498-507.

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