Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0426 Transporter Info
Gene Name	SLC5A6
Transporter Name	Sodium-dependent multivitamin transporter
Gene ID	8884
UniProt ID	Q9Y289

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	2,4-Dinitrophenol inhibits the reaction SLC5A6 protein results in increased transport of Biotin		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	4-Chloromercuribenzenesulfonate inhibits the reaction SLC5A6 protein results in increased transport of Biotin		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Azides inhibits the reaction SLC5A6 protein results in increased transport of Biotin		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	calmidazolium inhibits the reaction SLC5A6 protein results in increased transport of Biotin		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	chelerythrine inhibits the reaction SLC5A6 protein results in increased transport of Biotin		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	Gramicidin inhibits the reaction SLC5A6 protein results in increased transport of Biotin		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	Iodoacetates inhibits the reaction SLC5A6 protein results in increased transport of Biotin		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	Ouabain inhibits the reaction SLC5A6 protein results in increased transport of Biotin		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation9	Probenecid inhibits the reaction SLC5A6 protein results in increased transport of Biotin		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation10	SLC5A6 protein results in increased transport of Biotin		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation11	SLC5A6 results in increased transport of Biotin		[25]
Regulation Mechanism			Transcription Factor Info
DT Modulation12	SLC5A6 results in increased uptake of Biotin		[26]
Regulation Mechanism			Transcription Factor Info
DT Modulation13	Sodium affects the reaction SLC5A6 results in increased transport of Biotin		[25]
Regulation Mechanism			Transcription Factor Info
DT Modulation14	Sodium promotes the reaction SLC5A6 protein results in increased transport of Biotin		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation15	Staurosporine inhibits the reaction SLC5A6 protein results in increased transport of Biotin		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation16	Tetradecanoylphorbol Acetate promotes the reaction SLC5A6 protein results in increased transport of Biotin		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation17	Trifluoperazine inhibits the reaction SLC5A6 protein results in increased transport of Biotin		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Valproic Acid results in increased methylation of SLC5A6 gene		[36]
Regulation Mechanism			Transcription Factor Info
2,4-Dinitrophenol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2,4-Dinitrophenol inhibits the reaction SLC5A6 protein results in increased transport of Biotin		[1]
Regulation Mechanism			Transcription Factor Info
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid results in decreased expression of SLC5A6 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	LDN 193189 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein results in decreased expression of SLC5A6 protein		[21]
Regulation Mechanism			Transcription Factor Info
4-Chloromercuribenzenesulfonate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	4-Chloromercuribenzenesulfonate inhibits the reaction SLC5A6 protein results in increased transport of Biotin		[1]
Regulation Mechanism			Transcription Factor Info
4-phenylbutyric acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	4-phenylbutyric acid results in increased expression of SLC5A6 protein		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	mono-(2-ethylhexyl)phthalate inhibits the reaction 4-phenylbutyric acid results in increased expression of SLC5A6 protein		[22]
Regulation Mechanism			Transcription Factor Info
ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate results in decreased expression of SLC5A6 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
Azides	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Azides inhibits the reaction SLC5A6 protein results in increased transport of Biotin		[1]
Regulation Mechanism			Transcription Factor Info
Benzo(a)pyrene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene results in increased methylation of SLC5A6 5' UTR		[24]
Regulation Mechanism			Transcription Factor Info
bisphenol A	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol A affects the expression of SLC5A6 mRNA		[17]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	bisphenol A results in decreased expression of SLC5A6 protein		[27]
Regulation Mechanism			Transcription Factor Info
butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	butyraldehyde results in decreased expression of SLC5A6 mRNA		[15]
Regulation Mechanism			Transcription Factor Info
Cadmium Chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in decreased expression of SLC5A6 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
calmidazolium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	calmidazolium inhibits the reaction SLC5A6 protein results in increased transport of Biotin		[1]
Regulation Mechanism			Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to SLC5A6 gene		[29]
Regulation Mechanism			Transcription Factor Info
chelerythrine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	chelerythrine inhibits the reaction SLC5A6 protein results in increased transport of Biotin		[1]
Regulation Mechanism			Transcription Factor Info
cobaltous chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cobaltous chloride results in decreased expression of SLC5A6 mRNA		[30]
Regulation Mechanism			Transcription Factor Info
dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	dicrotophos results in increased expression of SLC5A6 mRNA		[16]
Regulation Mechanism			Transcription Factor Info
epigallocatechin gallate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	potassium chromate(VI) co-treated with epigallocatechin gallate results in decreased expression of SLC5A6 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
FR900359	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	FR900359 affects the phosphorylation of SLC5A6 protein		[32]
Regulation Mechanism			Transcription Factor Info
Gramicidin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Gramicidin inhibits the reaction SLC5A6 protein results in increased transport of Biotin		[1]
Regulation Mechanism			Transcription Factor Info
K 7174	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	K 7174 results in decreased expression of SLC5A6 mRNA		[14]
Regulation Mechanism			Transcription Factor Info
LDN 193189	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	LDN 193189 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein results in decreased expression of SLC5A6 protein		[21]
Regulation Mechanism			Transcription Factor Info
mono-(2-ethylhexyl)phthalate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	mono-(2-ethylhexyl)phthalate inhibits the reaction 4-phenylbutyric acid results in increased expression of SLC5A6 protein		[22]
Regulation Mechanism			Transcription Factor Info
Ouabain	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ouabain inhibits the reaction SLC5A6 protein results in increased transport of Biotin		[1]
Regulation Mechanism			Transcription Factor Info
Oxygen	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Oxygen deficiency results in decreased expression of SLC5A6 mRNA		[33]
Regulation Mechanism			Transcription Factor Info
Pantothenic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLC5A6 results in increased transport of Pantothenic Acid		[25]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Sodium affects the reaction SLC5A6 results in increased transport of Pantothenic Acid		[25]
Regulation Mechanism			Transcription Factor Info
perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	perfluorooctane sulfonic acid results in decreased expression of SLC5A6 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
perfluorooctanoic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	perfluorooctanoic acid results in decreased expression of SLC5A6 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
potassium chromate(VI)	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	potassium chromate(VI) co-treated with epigallocatechin gallate results in decreased expression of SLC5A6 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	potassium chromate(VI) results in decreased expression of SLC5A6 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
Probenecid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Probenecid inhibits the reaction SLC5A6 protein results in increased transport of Biotin		[1]
Regulation Mechanism			Transcription Factor Info
Silicon Dioxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Silicon Dioxide analog results in increased expression of SLC5A6 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
Sodium	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium affects the reaction SLC5A6 results in increased transport of Biotin		[25]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Sodium affects the reaction SLC5A6 results in increased transport of Pantothenic Acid		[25]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Sodium affects the reaction SLC5A6 results in increased transport of Thioctic Acid		[25]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Sodium promotes the reaction SLC5A6 protein results in increased transport of Biotin		[1]
Regulation Mechanism			Transcription Factor Info
sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in decreased expression of SLC5A6 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
Staurosporine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Staurosporine inhibits the reaction SLC5A6 protein results in increased transport of Biotin		[1]
Regulation Mechanism			Transcription Factor Info
Tetrachlorodibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tetrachlorodibenzodioxin affects the expression of SLC5A6 mRNA		[11]
Regulation Mechanism			Transcription Factor Info
Tetradecanoylphorbol Acetate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tetradecanoylphorbol Acetate promotes the reaction SLC5A6 protein results in increased transport of Biotin		[1]
Regulation Mechanism			Transcription Factor Info
Thioctic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLC5A6 results in increased transport of Thioctic Acid		[25]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Sodium affects the reaction SLC5A6 results in increased transport of Thioctic Acid		[25]
Regulation Mechanism			Transcription Factor Info
Thiram	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Thiram results in decreased expression of SLC5A6 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
Trifluoperazine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Trifluoperazine inhibits the reaction SLC5A6 protein results in increased transport of Biotin		[1]
Regulation Mechanism			Transcription Factor Info
Mycotoxins
Aflatoxin B1	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 results in increased methylation of SLC5A6 gene		[23]
Regulation Mechanism			Transcription Factor Info
Approved Drug
Copper Sulfate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate inhibits the expression of SLC5A6		[2]
Hydrogen Peroxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Hydrogen Peroxide affects the expression of SLC5A6		[3]
Isotretinoin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Isotretinoin inhibits the expression of SLC5A6		[4]
Arsenic Trioxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arsenic Trioxide increases the expression of SLC5A6		[5]
Valproic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid affects the expression of SLC5A6		[6]
Acetaminophen	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetaminophen increases the expression of SLC5A6		[7]
Estradiol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol increases the expression of SLC5A6		[8]
Gabapentin enacarbil	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Gabapentin enacarbil modulates the activity of SLC5A6		[9]
Phenylbutazone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Phenylbutazone inhibits the activity of SLC5A6		[10]
Drug Marketed but not Approved by US FDA
Biotin	18 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Biotin affects the expression of SLC5A6		[1]
Drug in Phase 2 Trial
Genistein	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Genistein increases the expression of SLC5A6		[12]
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bisphenol A affects the expression of SLC5A6		[17]
Drug in Preclinical Test
(+)-JQ1	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	(+)-JQ1 inhibits the expression of SLC5A6		[13]
Patented Pharmaceutical Agent
K-7174	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	K-7174 inhibits the expression of SLC5A6		[14]
Natural Product
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution increases the expression of SLC5A6		[19]
Environmental toxicant
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin affects the expression of SLC5A6		[11]
Pesticide/Insecticide
Dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dicrotophos increases the expression of SLC5A6		[16]
Health and Environmental Toxicant
Butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Butyraldehyde inhibits the expression of SLC5A6		[15]
Perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Perfluorooctane sulfonic acid inhibits the expression of SLC5A6		[18]

References
1	Biotin uptake by human proximal tubular epithelial cells: cellular and molecular aspects. Am J Physiol Renal Physiol. 2005 Apr;288(4):F823-31.
2	Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
3	Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203.
4	Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
5	Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
6	Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20.
7	Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
8	17 beta-Estradiol Activates HSF1 via MAPK Signaling in ER alpha-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533.
9	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
10	Major involvement of Na(+) -dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells. J Neurochem. 2015 Jul;134(1):97-112.
11	Cross-species comparisons of transcriptomic alterations in human and rat primary hepatocytes exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci. 2012 May;127(1):199-215.
12	Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
13	Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov. 2013 Mar;3(3):308-23.
14	A low-molecular-weight compound K7174 represses hepcidin: possible therapeutic strategy against anemia of chronic disease. PLoS One. 2013 Sep 27;8(9):e75568.
15	Integrated analysis of microRNA and mRNA expression profiles highlights aldehyde-induced inflammatory responses in cells relevant for lung toxicity. Toxicology. 2015 Aug 6;334:111-21.
16	Molecular mechanisms of discrotophos-induced toxicity in HepG2 cells: The role of CSA in oxidative stress. Food Chem Toxicol. 2017 May;103:253-260.
17	Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo. Environ Res. 2019 Jun;173:124-134.
18	An assessment of serum-dependent impacts on intracellular accumulation and genomic response of per- and polyfluoroalkyl substances in a placental trophoblast model. Environ Toxicol. 2020 Dec;35(12):1395-1405.
19	Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model. Arch Toxicol. 2021 May;95(5):1739-1761.
20	Altering cancer transcriptomes using epigenomic inhibitors. Epigenetics Chromatin. 2015 Feb 24;8:9.
21	Proteomics and disease network associations evaluation of environmentally relevant Bisphenol A concentrations in a human 3D neural stem cell model. Front Cell Dev Biol. 2023;11:1236243.
22	Di(2-ethylhexyl) phthalate induced thyroid toxicity via endoplasmic reticulum stress: In vivo and in vitro study. Environ Toxicol. 2022;37(12):2924-2936.
23	Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma. Toxicology. 2016 Mar 28;350-352:31-9.
24	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
25	Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization. J Biol Chem. 1999;274(21):14875-83.
26	Biotin uptake by human intestinal and liver epithelial cells: role of the SMVT system. Am J Physiol Gastrointest Liver Physiol. 2003;285(1):G73-7.
27	Low-dose Bisphenol A exposure alters the functionality and cellular environment in a human cardiomyocyte model. Environ Pollut. 2023;335:122359.
28	Evaluation of Cd-induced cytotoxicity in primary human keratinocytes. Hum Exp Toxicol. 2024;43:9603271231224458.
29	Identification of potential target genes of ROR-alpha in THP1 and HUVEC cell lines. Exp Cell Res. 2017;353(1):6-15.
30	Transcription and splicing regulation in human umbilical vein endothelial cells under hypoxic stress conditions by exon array. BMC Genomics. 2009;10:126.
31	Epigallocatechin-3-gallate (EGCG) protects against chromate-induced toxicity in vitro. Toxicol Appl Pharmacol. 2012 Jan 15;258(2):166-75.
32	Protein Kinase Signaling Networks Driven by Oncogenic Gq/11 in Uveal Melanoma Identified by Phosphoproteomic and Bioinformatic Analyses. Mol Cell Proteomics. 2023;22(11):100649.
33	Development of Long Noncoding RNA-Based Strategies to Modulate Tissue Vascularization. J Am Coll Cardiol. 2015;66(18):2005-2015.
34	High-throughput, quantitative assessment of the effects of low-dose silica nanoparticles on lung cells: grasping complex toxicity with a great depth of field. BMC Genomics. 2015;16(1):315.
35	High-Throughput Transcriptomics of Nontumorigenic Breast Cells Exposed to Environmentally Relevant Chemicals. Environ Health Perspect. 2024;132(4):47002.
36	Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.

Detail Information of Exogenous Modulation

Visitor Map

Correspondence