Drug Transporter (DT) Information

General Information of DT
DT ID DTD0384
Gene Name SLC4A3
Protein Name Anion exchange protein 3
Gene ID
6508
UniProt ID
P48751
TCDB ID
2.A.31.1.3
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:4YZF_A

Identity:55.773%

Minimized Score:-1810.804 kcal/mol

Detail: Structure Info

Synonyms AE 3; AE3; Anion exchanger 3; CAE3/BAE3; Cardiac/brain band 3-like protein; Neuronal band 3-like protein; SLC2C; SLC4A3; Solute carrier family 4 member 3
DT Family Anion Exchanger (AE) Family ;
Tissue Specificity Both BAE3 and CAE3 are expressed in failingventricle.
Function This transporter is a plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl(-)/HCO3(-) exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl(-).
Endogenous Substrate(s) Anions
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Anion exchange protein 3
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Anion exchange protein 3
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Anion exchange protein 3
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Anion exchange protein 3
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Anion exchange protein 3
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Anion exchange protein 3
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Anion exchange protein 3
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Anion exchange protein 3
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Anion exchange protein 3
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Bicarbonate
 Phase 3 Drug Info Metabolic acidosis 5C73 [1]
References
1 The SLC4 family of bicarbonate (HCO??) transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):159-82.

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