Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0384 Transporter Info
Gene Name	SLC4A3
Transporter Name	Anion exchange protein 3
Gene ID	6508
UniProt ID	P48751

Post-Translational Modification of This DT
Overview ofSLC4A3 Modification Sites with Functional and Structural Information
Sequence	M A N G V I P P P G G A S P L P Q V R V P L E E P P L S P D V E E E D D D L G K T L A V S R F G D L I S K P P A W D P E K P S R S Y S E R D F E F H R H T S H H T H H P L S A R L P P P H K L R R L P P T S A R H T R R K R K K E K T S A P P S E G T P P I Q E E G G A G V D E E E E E E E E E E G E S E A E P V E P P H S G T P Q K A K F S I G S D E D D S P G L P G R A A V T K P L P S V G P H T D K S P Q H S S S S P S P R A R A S R L A G E K S R P W S P S A S Y D L R E R L C P G S A L G N P G G P E Q Q V P T D E A E A Q M L G S A D L D D M K S H R L E D N P G V R R H L V K K P S R T Q G G R G S P S G L A P I L R R K K K K K K L D R R P H E V F V E L N E L M L D R S Q E P H W R E T A R W I K F E E D V E E E T E R W G K P H V A S L S F R S L L E L R R T I A H G A A L L D L E Q T T L P G I A H L V V E T M I V S D Q I R P E D R A S V L R T L L L K H S H P N D D K D S G F F P R N P S S S S M N S V L G N H H P T P S H G P D G A V P T M A D D L G E P A P L W P H D P D A K E K P L H M P G G D G H R G K S L K L L E K I P E D A E A T V V L V G C V P F L E Q P A A A F V R L N E A V L L E S V L E V P V P V R F L F V M L G P S H T S T D Y H E L G R S I A T L M S D K L F H E A A Y Q A D D R Q D L L S A I S E F L D G S I V I P P S E V E G R D L L R S V A A F Q R E L L R K R R E R E Q T K V E M T T R G G Y T A P G K E L S L E L G G S E A T P E D D P L L R T G S V F G G L V R D V R R R Y P H Y P S D L R D A L H S Q C V A A V L F I Y F A A L S P A I T F G G L L G E K T E G L M G V S E L I V S T A V L G V L F S L L G A Q P L L V V G F S G P L L V F E E A F F K F C R A Q D L E Y L T G R V W V G L W L V V F V L A L V A A E G S F L V R Y I S P F T Q E I F A F L I S L I F I Y E T F Y K L Y K V F T E H P L L P F Y P P E G A L E G S L D A G L E P N G S A L P P T E G P P S P R N Q P N T A L L S L I L M L G T F F I A F F L R K F R N S R F L G G K A R R I I G D F G I P I S I L V M V L V D Y S I T D T Y T Q K L T V P T G L S V T S P D K R S W F I P P L G S A R P F P P W M M V A A A V P A L L V L I L I F M E T Q I T A L I V S Q K A R R L L K G S G F H L D L L L I G S L G G L C G L F G L P W L T A A T V R S V T H V N A L T V M R T A I A P G D K P Q I Q E V R E Q R V T G V L I A S L V G L S I V M G A V L R R I P L A V L F G I F L Y M G V T S L S G I Q L S Q R L L L I L M P A K H H P E Q P Y V T K V K T W R M H L F T C I Q L G C I A L L W V V K S T A A S L A F P F L L L L T V P L R H C L L P R L F Q D R E L Q A L D S E D A E P N F D E D G Q D E Y N E L H M P V
PTM type	X-Oxidation X-Phosphorylation X-Phosphorylation X-Ubiquitination X-Ubiquitination X: Amino Acid

Oxidation
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A3			[1]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	236
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at SLC4A3 Cystine 236 has the potential to affect its expression or activity.
Phosphorylation
Alanine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A3			[2]
Role of PTM	Potential impacts
Modified Residue	Alanine	Modified Location	748
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A3 Alanine 748 has the potential to affect its expression or activity.
Glutamicacid	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A3			[3]
Role of PTM	Potential impacts
Modified Residue	Glutamicacid	Modified Location	324
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A3 Glutamicacid 324 has the potential to affect its expression or activity.
Leucine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A3			[2]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	743
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A3 Leucine 743 has the potential to affect its expression or activity.
Serine	16 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A3			[4], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	28
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A3 Serine 28 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC4A3			[6], [7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	67
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A3 Serine 67 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC4A3			[8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	167
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A3 Serine 167 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC4A3			[6], [8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	170
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A3 Serine 170 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC4A3			[4], [6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	175
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A3 Serine 175 has the potential to affect its expression or activity.
PTM Phenomenon6	.			[9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	198
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A3 Serine 198 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC4A3			[10], [11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	207
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A3 Serine 207 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC4A3			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	224
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A3 Serine 224 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC4A3			[3], [12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	297
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A3 Serine 297 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SLC4A3			[13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	299
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A3 Serine 299 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence SLC4A3			[14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	365
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A3 Serine 365 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence SLC4A3			[2], [14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	367
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A3 Serine 367 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence SLC4A3			[14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	370
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A3 Serine 370 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence SLC4A3			[15], [16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	580
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A3 Serine 580 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence SLC4A3			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	721
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A3 Serine 721 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence SLC4A3			[17]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	961
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A3 Serine 961 has the potential to affect its expression or activity.
Threonine	7 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A3			[13], [18]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	291
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A3 Threonine 291 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC4A3			[16]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	577
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A3 Threonine 577 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC4A3			[19]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	647
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A3 Threonine 647 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC4A3			[19]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	653
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A3 Threonine 653 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC4A3			[2]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	725
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A3 Threonine 725 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC4A3			[17]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	955
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A3 Threonine 955 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC4A3			[17]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	958
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A3 Threonine 958 has the potential to affect its expression or activity.
Tyrosine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A3			[20]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	696
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A3 Tyrosine 696 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC4A3			[2]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	716
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A3 Tyrosine 716 has the potential to affect its expression or activity.
Valine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A3			[2]
Role of PTM	Potential impacts
Modified Residue	Valine	Modified Location	752
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A3 Valine 752 has the potential to affect its expression or activity.
Ubiquitination
Glutamicacid	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A3			[21]
Role of PTM	Potential impacts
Modified Residue	Glutamicacid	Modified Location	320
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A3 Glutamicacid 320 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC4A3			[21]
Role of PTM	Potential impacts
Modified Residue	Glutamicacid	Modified Location	373
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A3 Glutamicacid 373 has the potential to affect its expression or activity.
Leucine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A3			[22]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	387
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A3 Leucine 387 has the potential to affect its expression or activity.
Lysine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A3			[21]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	346
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A3 Lysine 346 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC4A3			[22]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	360
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A3 Lysine 360 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[23]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	922
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A3 Lysine 922 has the potential to affect its expression or activity.
Serine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A3			[21]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	148
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A3 Serine 148 has the potential to affect its expression or activity.

References
1	A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell. 2020 Mar 5;180(5):968-983.e24.
2	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
3	Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling. Mol Cell. 2020 Mar 5;77(5):1124-1142.e10.
4	Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation. Nat Immunol. 2013 Nov;14(11):1166-72.
5	Phosphoproteomic analysis of human brain by calcium phosphate precipitation and mass spectrometry. J Proteome Res. 2008 Jul;7(7):2845-51.
6	Refined phosphopeptide enrichment by phosphate additive and the analysis of human brain phosphoproteome. Proteomics. 2015 Jan;15(2-3):500-7.
7	Molecular basis for angiotensin II-induced increase of chloride/bicarbonate exchange in the myocardium. Circ Res. 2001 Dec 7;89(12):1246-53.
8	Quantitative phosphoproteomics of Alzheimer's disease reveals cross-talk between kinases and small heat shock proteins. Proteomics. 2015 Jan;15(2-3):508-519.
9	BioMuta and BioXpress: mutation and expression knowledgebases for cancer biomarker discovery. Nucleic Acids Res. 2018;46(D1):D1128-D1136.
10	Comparative N-glycoproteomic and phosphoproteomic profiling of human placental plasma membrane between normal and preeclampsia pregnancies with high-resolution mass spectrometry. PLoS One. 2013 Nov 15;8(11):e80480.
11	Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48.
12	Offline pentafluorophenyl (PFP)-RP prefractionation as an alternative to high-pH RP for comprehensive LC-MS/MS proteomics and phosphoproteomics. Anal Bioanal Chem. 2017 Jul;409(19):4615-4625.
13	Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res. 2013 Jun 7;12(6):2414-21.
14	System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal. 2011 Mar 15;4(164):rs3.
15	Systematic functional prioritization of protein posttranslational modifications. Cell. 2012 Jul 20;150(2):413-25.
16	Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3.
17	Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra. J Proteome Res. 2007 Nov;6(11):4150-62.
18	Phosphoproteome profiling of human skin fibroblast cells in response to low- and high-dose irradiation. J Proteome Res. 2006 May;5(5):1252-60.
19	An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62.
20	Quantitative phosphoproteomics identifies substrates and functional modules of Aurora and Polo-like kinase activities in mitotic cells. Sci Signal. 2011 Jun 28;4(179):rs5.
21	Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Nature. 2013 Apr 18;496(7445):372-6.
22	UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites. Nat Struct Mol Biol. 2018 Jul;25(7):631-640.
23	15 years of PhosphoSitePlus?: integrating post-translationally modified sites, disease variants and isoforms. Nucleic Acids Res. 2019;47(D1):D433-D441.

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Detail Information of Post-Translational Modifications

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