Drug Transporter (DT) Information

General Information of DT
DT ID DTD0364
Gene Name SLC44A2
Protein Name Choline transporter-like protein 2
Gene ID
57153
UniProt ID
Q8IWA5
TCDB ID
2.A.92.1.4
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms CTL2; PP1292; SLC44A2; Solute carrier family 44 member 2
DT Family Choline Transporter-Like (CTl) Family ;
Tissue Specificity Present in supporting cells of the inner ear(at protein level). Only isoform 3 is expressed in inner earvestibular tissue.
Function This isoform 1 of this transporter mediates choline transport.
Endogenous Substrate(s) Choline
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Choline transporter-like protein 2
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Choline transporter-like protein 2
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Choline transporter-like protein 2
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Choline transporter-like protein 2
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Choline transporter-like protein 2
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Choline transporter-like protein 2
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Choline transporter-like protein 2
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Choline transporter-like protein 2
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Choline transporter-like protein 2
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Choline
 Phase 3 Drug Info Elderly bronchial asthma CA23 [1]
References
1 The choline transporter-like family SLC44: properties and roles in human diseases. Mol Aspects Med. 2013 Apr-Jun;34(2-3):646-54.

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