Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID DTD0364 Transporter Info
Gene Name SLC44A2
Transporter Name Choline transporter-like protein 2
Gene ID
57153
UniProt ID
Q8IWA5
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Chemical Compound

  DT Modulation1

 Copper Sulfate results in increased expression of SLC44A2 mRNA [2]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation1

 Cyclosporine results in increased expression of SLC44A2 mRNA [28]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation1

 Ethanol results in increased expression of SLC44A2 mRNA [30]

Regulation Mechanism

 Transcription Factor Info

  2,4,6-tribromophenol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 2,4,6-tribromophenol results in increased expression of SLC44A2 mRNA [15]

Regulation Mechanism

 Transcription Factor Info

  2-bromopalmitate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 2-bromopalmitate inhibits the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of SLC44A2 protein [18]

Regulation Mechanism

 Transcription Factor Info

  4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid results in increased expression of SLC44A2 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 LDN 193189 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein results in increased expression of SLC44A2 protein [19]

Regulation Mechanism

 Transcription Factor Info

  aristolochic acid I

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 aristolochic acid I results in increased expression of SLC44A2 mRNA [20]

Regulation Mechanism

 Transcription Factor Info

  Benzo(a)pyrene

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Benzo(a)pyrene affects the methylation of SLC44A2 promoter [22]

Regulation Mechanism

 Transcription Factor Info

  beta-lapachone

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 beta-lapachone results in increased expression of SLC44A2 mRNA [23]

Regulation Mechanism

 Transcription Factor Info

  bisphenol A

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 bisphenol A results in decreased expression of SLC44A2 protein [15]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 bisphenol A results in increased expression of SLC44A2 mRNA [24]

Regulation Mechanism

 Transcription Factor Info

  bisphenol AF

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 bisphenol AF results in increased expression of SLC44A2 mRNA [25]

Regulation Mechanism

 Transcription Factor Info

  bisphenol S

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 bisphenol S results in increased expression of SLC44A2 mRNA [25]

Regulation Mechanism

 Transcription Factor Info

  Cadmium Chloride

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 2-bromopalmitate inhibits the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of SLC44A2 protein [18]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of SLC44A2 protein [18]

Regulation Mechanism

 Transcription Factor Info

  Cisplatin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cisplatin co-treated with jinfukang results in increased expression of SLC44A2 mRNA [13]

Regulation Mechanism

 Transcription Factor Info

  Copper

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Disulfiram binds to Copper which results in increased expression of SLC44A2 mRNA [26]

Regulation Mechanism

 Transcription Factor Info

  cupric chloride

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 cupric chloride results in decreased expression of SLC44A2 mRNA [27]

Regulation Mechanism

 Transcription Factor Info

  decabromobiphenyl ether

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 decabromobiphenyl ether results in increased expression of SLC44A2 protein [15]

Regulation Mechanism

 Transcription Factor Info

  Disulfiram

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Disulfiram binds to Copper which results in increased expression of SLC44A2 mRNA [26]

Regulation Mechanism

 Transcription Factor Info

  Estradiol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Estradiol co-treated with Progesterone results in increased expression of SLC44A2 mRNA [29]

Regulation Mechanism

 Transcription Factor Info

  Fonofos

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Fonofos results in increased methylation of SLC44A2 promoter [31]

Regulation Mechanism

 Transcription Factor Info

  Furaldehyde

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Sodium Chloride co-treated with Furaldehyde results in decreased expression of and affects the localization of SLC44A2 protein [32]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Sodium Chloride co-treated with Furaldehyde results in increased expression of SLC44A2 protein [32]

Regulation Mechanism

 Transcription Factor Info

  hydroxyhydroquinone

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 hydroxyhydroquinone results in decreased expression of SLC44A2 mRNA [33]

Regulation Mechanism

 Transcription Factor Info

  ICG 001

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 ICG 001 results in increased expression of SLC44A2 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  Lactic Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Lactic Acid results in decreased expression of SLC44A2 mRNA [14]

Regulation Mechanism

 Transcription Factor Info

  LDN 193189

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 LDN 193189 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein results in increased expression of SLC44A2 protein [19]

Regulation Mechanism

 Transcription Factor Info

  methyleugenol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 methyleugenol results in increased expression of SLC44A2 mRNA [16]

Regulation Mechanism

 Transcription Factor Info

  Mustard Gas

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Mustard Gas results in increased expression of SLC44A2 mRNA [34]

Regulation Mechanism

 Transcription Factor Info

  N-Nitrosopyrrolidine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 N-Nitrosopyrrolidine results in increased expression of SLC44A2 mRNA [16]

Regulation Mechanism

 Transcription Factor Info

  Parathion

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Parathion results in increased methylation of SLC44A2 promoter [31]

Regulation Mechanism

 Transcription Factor Info

  Progesterone

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Estradiol co-treated with Progesterone results in increased expression of SLC44A2 mRNA [29]

Regulation Mechanism

 Transcription Factor Info

  pyrogallol 1,3-dimethyl ether

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Sodium Chloride co-treated with pyrogallol 1,3-dimethyl ether results in increased expression of and affects the localization of SLC44A2 protein [32]

Regulation Mechanism

 Transcription Factor Info

  resorcinol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 resorcinol results in decreased expression of SLC44A2 mRNA [10]

Regulation Mechanism

 Transcription Factor Info

  Rotenone

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Rotenone results in increased expression of SLC44A2 protein [35]

Regulation Mechanism

 Transcription Factor Info

  S-(1,2-dichlorovinyl)cysteine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides results in decreased expression of SLC44A2 mRNA [36]

Regulation Mechanism

 Transcription Factor Info

  Silicon Dioxide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Silicon Dioxide analog results in decreased expression of SLC44A2 mRNA [37]

Regulation Mechanism

 Transcription Factor Info

  sodium arsenite

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 sodium arsenite results in decreased expression of SLC44A2 mRNA [27]

Regulation Mechanism

 Transcription Factor Info

  Sodium Chloride

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Sodium Chloride co-treated with Furaldehyde results in decreased expression of and affects the localization of SLC44A2 protein [32]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Sodium Chloride co-treated with Furaldehyde results in increased expression of SLC44A2 protein [32]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 Sodium Chloride co-treated with pyrogallol 1,3-dimethyl ether results in increased expression of and affects the localization of SLC44A2 protein [32]

Regulation Mechanism

 Transcription Factor Info

  terbufos

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 terbufos results in increased methylation of SLC44A2 promoter [31]

Regulation Mechanism

 Transcription Factor Info

  tetrabromobisphenol A

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 tetrabromobisphenol A results in increased expression of SLC44A2 protein [15]

Regulation Mechanism

 Transcription Factor Info

  triphenyl phosphate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 triphenyl phosphate affects the expression of SLC44A2 mRNA [38]

Regulation Mechanism

 Transcription Factor Info

Carcinogen

  DT Modulation1

 Arsenic affects the methylation of SLC44A2 gene [21]

Regulation Mechanism

 Transcription Factor Info

  Cadmium

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 2-bromopalmitate inhibits the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of SLC44A2 protein [18]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of SLC44A2 protein [18]

Regulation Mechanism

 Transcription Factor Info

Approved Drug

  Arsenic

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Arsenic affects the expression of SLC44A2 [1]

  Copper Sulfate

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Copper Sulfate inhibits the expression of SLC44A2 [2]

  Zoledronic Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Zoledronic Acid inhibits the expression of SLC44A2 [3]

  Cyclosporine

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cyclosporine inhibits the expression of SLC44A2 [4]

  Urethane

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Urethane increases the expression of SLC44A2 [5]

  Leflunomide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Leflunomide increases the expression of SLC44A2 [6]

  Doxorubicin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Doxorubicin affects the expression of SLC44A2 [7]

  Valproic Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Valproic Acid increases the expression of SLC44A2 [8]

  Ethanol

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Ethanol induces the activity of SLC44A2 [9]

Drug in Phase 2 Trial

  Bisphenol A

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Bisphenol A inhibits the expression of SLC44A2 [15]

Investigative Drug

  Milchsaure

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Milchsaure inhibits the expression of SLC44A2 [14]

Patented Pharmaceutical Agent

  ICG-001

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 ICG-001 increases the expression of SLC44A2 [12]

Natural Product

  Methyleugenol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Methyleugenol increases the expression of SLC44A2 [16]

  Tobacco Smoke Pollution

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Tobacco Smoke Pollution inhibits the expression of SLC44A2 [17]

Traditional Medicine

  Jinfukang

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Jinfukang increases the expression of SLC44A2 [13]

Environmental toxicant

  Resorcinol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Resorcinol inhibits the expression of SLC44A2 [10]

  Tetrabromobisphenol A

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Tetrabromobisphenol A increases the expression of SLC44A2 [15]

Health and Environmental Toxicant

  tris(1,3-dichloro-2-propyl)phosphate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 tris(1,3-dichloro-2-propyl)phosphate increases the expression of SLC44A2 [11]
References
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2 Extremely low copper concentrations affect gene expression profiles of human prostate epithelial cell lines. Chem Biol Interact. 2010 Oct 6;188(1):214-9.
3 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
4 Evidence for a role of claudin 2 as a proximal tubular stress responsive paracellular water channel. Toxicol Appl Pharmacol. 2014 Sep 1;279(2):163-72.
5 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
6 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
7 Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
8 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
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12 Altering cancer transcriptomes using epigenomic inhibitors. Epigenetics Chromatin. 2015 Feb 24;8:9.
13 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
14 Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
15 Environmental pollutant induced cellular injury is reflected in exosomes from placental explants. Placenta. 2020 Jan 1;89:42-49.
16 Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297.
17 Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model. Arch Toxicol. 2021 May;95(5):1739-1761.
18 Protein S-palmitoylation enhances profibrotic signaling in response to cadmium. Toxicol Appl Pharmacol. 2024;483:116806.
19 Proteomics and disease network associations evaluation of environmentally relevant Bisphenol A concentrations in a human 3D neural stem cell model. Front Cell Dev Biol. 2023;11:1236243.
20 Integration of transcriptomic, proteomic and metabolomic data to reveal the biological mechanisms of AAI injury in renal epithelial cells. Toxicol In Vitro. 2021;70:105054.
21 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106.
22 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
23 Lapachone induces ferroptosis of colorectal cancer cells via NCOA4-mediated ferritinophagy by activating JNK pathway. Chem Biol Interact. 2024;389:110866.
24 Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
25 Genome-wide gene expression profiling of low-dose, long-term exposure of human osteosarcoma cells to bisphenol A and its analogs bisphenols AF and S. Toxicol In Vitro. 2015 Aug;29(5):1060-9.
26 Disulfiram suppresses growth of the malignant pleural mesothelioma cells in part by inducing apoptosis. PLoS One. 2014;9(4):e93711.
27 High-Throughput Transcriptomics of Nontumorigenic Breast Cells Exposed to Environmentally Relevant Chemicals. Environ Health Perspect. 2024;132(4):47002.
28 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
29 Ovarian steroids, mitogen-activated protein kinases, and/or aspartic proteinases cooperate to control endometrial remodeling by regulating gene expression in the stroma and glands. Endocrinology. 2010;151(9):4515-26.
30 Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
31 DNA methylation alterations in response to pesticide exposure in vitro. Environ Mol Mutagen. 2012;53(7):542-9.
32 Human Keratinocyte Responses to Woodsmoke Chemicals. Chem Res Toxicol. 2024;37(5):675-684.
33 1,2,4-trihydroxybenzene induces non-apoptotic cell death via the structural damage of intracellular organelles. Toxicol Appl Pharmacol. 2024;492:117096.
34 Whole genome expression analysis in primary bronchial epithelial cells after exposure to sulphur mustard. Toxicol Lett. 2014;230(3):393-401.
35 Proteomic analysis of human iPSC-derived sympathetic neurons identifies proteostasis collapse as a molecular signature following subtoxic rotenone exposure. Toxicology. 2025;510:154015.
36 The trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine inhibits lipopolysaccharide-induced inflammation transcriptomic pathways and cytokine secretion in a macrophage cell model. Toxicol In Vitro. 2022;84:105429.
37 High-throughput, quantitative assessment of the effects of low-dose silica nanoparticles on lung cells: grasping complex toxicity with a great depth of field. BMC Genomics. 2015;16(1):315.
38 Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60-69 Years of Age: Evidence from the China BAPE Study. Environ Health Perspect. 2023;131(4):47009.

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