Drug Transporter (DT) Information

General Information of DT
DT ID DTD0333
Gene Name SLC38A6
Protein Name Probable sodium-coupled neutral amino acid transporter 6
Gene ID
145389
UniProt ID
Q8IZM9
TCDB ID
2.A.18.6.11
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms N-system amino acid transporter 1; NAT-1; NAT1; Na(+)-coupled neutral amino acid transporter 6; SLC38A6; SNAT6; Solute carrier family 38 member 6
DT Family Amino Acid/Auxin Permease (AAAP) Family ;
Function This sodium-dependent amino acid/proton antiporter could be a neuronal transporter for glutamate.
Endogenous Substrate(s) Glutamine
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Probable sodium-coupled neutral amino acid transporter 6
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Probable sodium-coupled neutral amino acid transporter 6
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Probable sodium-coupled neutral amino acid transporter 6
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Probable sodium-coupled neutral amino acid transporter 6
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Probable sodium-coupled neutral amino acid transporter 6
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Probable sodium-coupled neutral amino acid transporter 6
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Probable sodium-coupled neutral amino acid transporter 6
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Probable sodium-coupled neutral amino acid transporter 6
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Probable sodium-coupled neutral amino acid transporter 6
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Amino acids
 Approved Drug Info Nutritional deficiency 5B7Z [1]
References
1 Histological analysis of SLC38A6 (SNAT6) expression in mouse brain shows selective expression in excitatory neurons with high expression in the synapses. PLoS One. 2014 Apr 21;9(4):e95438.

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