Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0333 Transporter Info
Gene Name SLC38A6
Transporter Name Probable sodium-coupled neutral amino acid transporter 6
Gene ID
145389
UniProt ID
Q8IZM9

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 10 TF(s) Regulating This DT

        ATF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [1]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-1 Transcription Factor Info

Tissue

 Bone marrow; Colon; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-1 (ATF1) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

        ATF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [2]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-3 Transcription Factor Info

Tissue

 Blood; Bone marrow; Colon; Embryo; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

        BACH1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [3]

TF Protein Name

 Transcription regulator protein BACH1 Transcription Factor Info

Tissue

 Bone marrow; Embryo

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription regulator protein BACH1 (BACH1) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

        BACH2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [3]

TF Protein Name

 Transcription regulator protein BACH2 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription regulator protein BACH2 (BACH2) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

        CEBPB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [4]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Bone

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [1]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Blood; Bone marrow; Colon; Embryo; Liver; Lung; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

        FOS 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [2]

TF Protein Name

 Protein c-Fos Transcription Factor Info

Tissue

 Breast; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein c-Fos (FOS) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

        MAFF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [4]

TF Protein Name

 Transcription factor MafF Transcription Factor Info

Tissue

 Bone marrow; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor MafF (MAFF) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

        MAFK 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [1]

TF Protein Name

 Transcription factor MafK Transcription Factor Info

Tissue

 Blood; Bone marrow; Cervix; Embryo; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor MafK (MAFK) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

        NFE2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [3]

TF Protein Name

 Transcription factor NF-E2 45 kDa subunit Transcription Factor Info

Tissue

 Blood; Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor NF-E2 45 kDa subunit (NFE2) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        MAX 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [2]

TF Protein Name

 Protein max Transcription Factor Info

Tissue

 Blood; Bone marrow; Brain; Breast; Cervix; Colon; Embryo; Liver; Lung; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein max (MAX) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

        MITF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [3]

TF Protein Name

 Microphthalmia-associated transcription factor Transcription Factor Info

Tissue

 Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Microphthalmia-associated transcription factor (MITF) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

        TCF21 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [4]

TF Protein Name

 Transcription factor 21 Transcription Factor Info

Tissue

 Coronary artery

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor 21 (TCF21) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

        USF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [1]

TF Protein Name

 Upstream stimulatory factor 1 Transcription Factor Info

Tissue

 Bone marrow; Brain; Embryo; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Upstream stimulatory factor 1 (USF1) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

        USF2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [2]

TF Protein Name

 Upstream stimulatory factor 2 Transcription Factor Info

Tissue

 Cervix

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Upstream stimulatory factor 2 (USF2) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        VDR 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC38A6 gene in leukemia condition [5]

TF Protein Name

 Vitamin D3 receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Vitamin D3 receptor (VDR) has been reported to activate the transcription of SLC38A6 gene in leukemia condition, which leads to an increased expression of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

       Transcriptional Phenomenon2

 Binding to SLC38A6 gene in THP-1 human monocytic leukemia cells condition [6]

TF Protein Name

 Vitamin D3 receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Vitamin D3 receptor (VDR) has been reported to bind to the transcription of SLC38A6 gene in THP-1 human monocytic leukemia cells condition, which leads to an affected expression of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GATA6 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC38A6 gene in gastric cancer condition [7]

TF Protein Name

 Transcription factor GATA-6 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor GATA-6 (GATA6) has been reported to activate the transcription of SLC38A6 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        KLF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [3]

TF Protein Name

 Krueppel-like factor 1 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 1 (KLF1) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

        KLF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [4]

TF Protein Name

 Krueppel-like factor 4 Transcription Factor Info

Tissue

 Foreskin; Pancreatic ductal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 4 (KLF4) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

        KLF5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [2]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Tissue

 Pancreatic ductal; Stomach

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 5 (KLF5) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [1]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Bone marrow; Cervix; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

        ZNF263 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [3]

TF Protein Name

 Zinc finger protein 263 Transcription Factor Info

Tissue

 Bone marrow; Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 263 (ZNF263) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        CUX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC38A6 gene in multiple human cancer types condition [8]

TF Protein Name

 Homeobox protein cut-like 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Homeobox protein cut-like 1 (CUX1) has been reported to activate the transcription of SLC38A6 gene in multiple human cancer types condition, which leads to an increased expression of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        E2F1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [4]

TF Protein Name

 Transcription factor E2F1 Transcription Factor Info

Tissue

 Mesenchymal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F1 (E2F1) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

        E2F4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC38A6 gene in health condition [9]

TF Protein Name

 Transcription factor E2F4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor E2F4 (E2F4) has been reported to bind to the transcription of SLC38A6 gene in health condition, which leads to an affected expression of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

        FOXA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [3]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Tissue

 Breast; Embryo; Liver; Lung; Pancreatic ductal; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [4]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Tissue

 Embryo; Endoderm; Liver; Lung; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

        FOXP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [3]

TF Protein Name

 Forkhead box protein P1 Transcription Factor Info

Tissue

 Embryo; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Forkhead box protein P1 (FOXP1) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 6 TF(s) Regulating This DT

        ERG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [1]

TF Protein Name

 Transcriptional regulator ERG Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional regulator ERG (ERG) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

        ETS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [2]

TF Protein Name

 Protein C-ets-1 Transcription Factor Info

Tissue

 Blood; Bone marrow; Kidney; Lung; Prostate; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein C-ets-1 (ETS1) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

        FLI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [2]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [4]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Blood; Bone marrow; Brain; Breast; Liver; Lung; Mesenchymal; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

        IRF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [1]

TF Protein Name

 Interferon regulatory factor 1 Transcription Factor Info

Tissue

 Blood; Bone marrow; Pancreatic ductal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Interferon regulatory factor 1 (IRF1) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

        IRF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [1]

TF Protein Name

 Interferon regulatory factor 4 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Interferon regulatory factor 4 (IRF4) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

TF Superclass6: Immunoglobulin fold

      Class6.2: STAT domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        STAT3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC38A6 gene in glioblastoma multiforme condition [10]

TF Protein Name

 Signal transducer and activator of transcription 3 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Signal transducer and activator of transcription 3 (STAT3) has been reported to activate the transcription of SLC38A6 gene in glioblastoma multiforme condition, which leads to an increased expression of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

      Class6.3: p53 domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TP53 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC38A6 gene in stress response condition [11]

TF Protein Name

 Cellular tumor antigen p53 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of SLC38A6 gene in stress response condition, which leads to an affected expression of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.

TF Superclass10: Yet undefined DNA-binding domains

      Class10.1: Other factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GTF2B 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A6 gene [2]

TF Protein Name

 Transcription initiation factor IIB Transcription Factor Info

Tissue

 Cervix; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription initiation factor IIB (GTF2B) can directly bind to the SLC38A6 gene, which in turn affects the expression or function of the drug transporter Probable sodium-coupled neutral amino acid transporter 6.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-292. (ID:ENSG00000139974)
2 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
3 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
4 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
5 Characterization of genomic vitamin D receptor binding sites through chromatin looping and opening. PLoS One. 2014;9(4):e96184.
6 Patterns of genome-wide VDR locations. PLoS One. 2014;9(4):e96105.
7 Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
8 p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin. J Biol Chem. 2009;284(40):27701-11.
9 Wide-ranging functions of E2F4 in transcriptional activation and repression revealed by genome-wide analysis. Nucleic Acids Res. 2011;39(9):3558-73.
10 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
11 Characterization of genome-wide p53-binding sites upon stress response. Nucleic Acids Res. 2008;36(11):3639-54.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.