| General Information of DT | |||||
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| DT ID | DTD0232 | ||||
| Gene Name | SLC26A4 | ||||
| Protein Name | Sodium-independent chloride/iodide transporter | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:6RTC_A Identity:38.559% Minimized Score:-1329.565 kcal/mol Detail: Structure Info |
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| Synonyms | DFNB4; EVA; PDS; Pendrin; SLC26A4; Solute carrier family 26 member 4; TDH2B | ||||
| DT Family | Sulfate Permease (SULP) Family ; | ||||
| Tissue Specificity | High expression in adult thyroid, lowerexpression in adult and fetal kidney and fetal brain. Notexpressed in other tissues. | ||||
| Function | This transporter is sodium-independent transporter of chloride and iodide. | ||||
| Endogenous Substrate(s) | Cl-; I-; Bicarbonate; Cyanate; Thiocyanate | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Sodium-independent chloride/iodide transporter |
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(β) Cell Distribution Level of Sodium-independent chloride/iodide transporter |
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(γ) Organelle Distribution Level of Sodium-independent chloride/iodide transporter |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Sodium-independent chloride/iodide transporter |
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(γ) Transcriptional Regulation of Sodium-independent chloride/iodide transporter |
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(δ) Epigenetic Regulation of Sodium-independent chloride/iodide transporter |
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(ε) Exogenous Modulation of Sodium-independent chloride/iodide transporter |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Sodium-independent chloride/iodide transporter |
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(β) Disease-specific Protein Abundances of Sodium-independent chloride/iodide transporter |
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(γ) Species- and Tissue-specific DT Abundances |
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