Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0232 Transporter Info
Gene Name	SLC26A4
Transporter Name	Sodium-independent chloride/iodide transporter
Gene ID	5172
UniProt ID	O43511

Post-Translational Modification of This DT
Overview ofSLC26A4 Modification Sites with Functional and Structural Information
Sequence	M A A P G G R S E P P Q L P E Y S C S Y M V S R P V Y S E L A F Q Q Q H E R R L Q E R K T L R E S L A K C C S C S R K R A F G V L K T L V P I L E W L P K Y R V K E W L L S D V I S G V S T G L V A T L Q G M A Y A L L A A V P V G Y G L Y S A F F P I L T Y F I F G T S R H I S V G P F P V V S L M V G S V V L S M A P D E H F L V S S S N G T V L N T T M I D T A A R D T A R V L I A S A L T L L V G I I Q L I F G G L Q I G F I V R Y L A D P L V G G F T T A A A F Q V L V S Q L K I V L N V S T K N Y N G V L S I I Y T L V E I F Q N I G D T N L A D F T A G L L T I V V C M A V K E L N D R F R H K I P V P I P I E V I V T I I A T A I S Y G A N L E K N Y N A G I V K S I P R G F L P P E L P P V S L F S E M L A A S F S I A V V A Y A I A V S V G K V Y A T K Y D Y T I D G N Q E F I A F G I S N I F S G F F S C F V A T T A L S R T A V Q E S T G G K T Q V A G I I S A A I V M I A I L A L G K L L E P L Q K S V L A A V V I A N L K G M F M Q L C D I P R L W R Q N K I D A V I W V F T C I V S I I L G L D L G L L A G L I F G L L T V V L R V Q F P S W N G L G S I P S T D I Y K S T K N Y K N I E E P Q G V K I L R F S S P I F Y G N V D G F K K C I K S T V G F D A I R V Y N K R L K A L R K I Q K L I K S G Q L R A T K N G I I S D A V S T N N A F E P D E D I E D L E E L D I P T K E I E I Q V D W N S E L P V K V N V P K V P I H S L V L D C G A I S F L D V V G V R S L R V I V K E F Q R I D V N V Y F A S L Q D Y V I E K L E Q C G F F D D N I R K D T F F L T V H D A I L Y L Q N Q V K S Q E G Q G S I L E T I T L I Q D C K D T L E L I E T E L T E E E L D V Q D E A M R T L A S
PTM type	X-Acetylation X-Phosphorylation X-Phosphorylation X-Ubiquitination X: Amino Acid

Acetylation
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	681
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLC26A4 Lysine 681 has the potential to affect its expression or activity.
Phosphorylation
Serine	9 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC26A4			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	17
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC26A4 Serine 17 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[1]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	137
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC26A4 Serine 137 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[1]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	137
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC26A4 Serine 137 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[1]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	145
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC26A4 Serine 145 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC26A4			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	355
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC26A4 Serine 355 has the potential to affect its expression or activity.
PTM Phenomenon6	.			[1]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	448
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC26A4 Serine 448 has the potential to affect its expression or activity.
PTM Phenomenon7	.			[1]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	526
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC26A4 Serine 526 has the potential to affect its expression or activity.
PTM Phenomenon8	.			[1]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	526
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC26A4 Serine 526 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC26A4			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	642
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC26A4 Serine 642 has the potential to affect its expression or activity.
Threonine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC26A4			[4]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	631
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC26A4 Threonine 631 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC26A4			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	717
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC26A4 Threonine 717 has the potential to affect its expression or activity.
Tyrosine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC26A4			[2]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	16
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC26A4 Tyrosine 16 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC26A4			[2]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	20
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC26A4 Tyrosine 20 has the potential to affect its expression or activity.
Ubiquitination
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	601
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC26A4 Lysine 601 has the potential to affect its expression or activity.

References
1	15 years of PhosphoSitePlus?: integrating post-translationally modified sites, disease variants and isoforms. Nucleic Acids Res. 2019;47(D1):D433-D441.
2	iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics. Mol Cell Proteomics. 2012 Jun;11(6):M111.014423.
3	Robust, Reproducible, and Economical Phosphopeptide Enrichment Using Calcium Titanate. J Proteome Res. 2019 Mar 1;18(3):1411-1417.
4	An Augmented Multiple-Protease-Based Human Phosphopeptide Atlas. Cell Rep. 2015 Jun 23;11(11):1834-43.
5	TSH regulates pendrin membrane abundance and enhances iodide efflux in thyroid cells. Endocrinology. 2012 Jan;153(1):512-21.

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Detail Information of Post-Translational Modifications

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