General Information of Drug Transporter (DT)
DT ID DTD0232 Transporter Info
Gene Name SLC26A4
Protein Name Sodium-independent chloride/iodide transporter
Gene ID
5172
UniProt ID
O43511
3D Structure

Modelled Stucture

Method:Homology modeling

Teplate PDB:6RTC_A

Identity:38.559%

Minimized Score:-1329.565

Detail: Structure Info

Inter-species Structural Differences (ISD)
Mus musculus (Mouse)
        Gene Name Slc26a4
        UniProt ID
Q9R155
        UniProt Entry
S26A4_MOUSE
        3D Structure

Method:Homology modeling

Teplate PDB:7CH1_A

Sequence Length:715

Identity:35.31%

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        Performance Minimized Score -1871.464 kcal/mol
Ramachandra Favored

Excellent

QMEANBrane Quality

High

        Ramachandran Plot

Ramz Z Score:-0.4 ±0.3

Residues in Favored Region:701

Ramachandran favored:98.32%

Number of Outliers:1

Ramachandran outliers:0.14%

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        Local Quality

QMEANBrane Score:0.79

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Rattus norvegicus (Rat)
        Gene Name Slc26a4
        UniProt ID
Q9R154
        UniProt Entry
S26A4_RAT
        3D Structure

Method:Homology modeling

Teplate PDB:7CH1_A

Sequence Length:715

Identity:35.887%

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        Performance Minimized Score -1805.575 kcal/mol
Ramachandra Favored

Medium

QMEANBrane Quality

High

        Ramachandran Plot

Ramz Z Score:-0.48 ±0.29

Residues in Favored Region:694

Ramachandran favored:97.34%

Number of Outliers:3

Ramachandran outliers:0.42%

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        Local Quality

QMEANBrane Score:0.79

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References
1 Asymmetric pendrin homodimer reveals its molecular mechanism as anion exchanger. Nat Commun. 2023;14(1):3012.

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